Current Concept Review: Risk Factors for Infection Following Open Fractures

被引：16

作者：

Coombs, Jeffrey ^{[1
,2
]}

Billow, Damien ^{[1
]}

Cereijo, Cesar ^{[1
]}

Patterson, Brendan ^{[1
]}

Pinney, Stephen ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Orthopaed & Rheumatol Inst, Cleveland, OH 44195 USA

[2] Case Western Reserve Univ, Sch Med, Cleveland, OH USA

来源：

ORTHOPEDIC RESEARCH AND REVIEWS | 2022年 / 14卷

关键词：

open fracture; antibiotic prophylaxis; trauma; infection; OPEN TIBIA FRACTURES; PRESSURE WOUND THERAPY; INTEROBSERVER RELIABILITY; PROPHYLACTIC ANTIBIOTICS; SMOKING-CESSATION; MANAGEMENT; CLASSIFICATION; CLOSURE; SURGERY; GUSTILO;

D O I：

10.2147/ORR.S384845

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Infection following open fracture is a significant source of morbidity and mortality. Therefore, a central tenet of treatment is to minimize the risk of infection. The initial risk of infection is determined by wound characteristics, such as size, soft tissue coverage, vascular injury, and contamination. While no consensus exists on optimal antibiotic regimen, early administration of prophylactic antibiotics, within an hour of injury, when possible, has been shown definitively to decrease the risk of infection. Infection risk is further reduced by early irrigation with normal saline and aggressive debridement of devitalized tissue. Patient factors that increase risk of infection following open fracture include diabetes mellitus, smoking, male gender, and lower extremity fracture.

引用

页码：383 / 391

页数：9

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