Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillin in ICR mice

被引：28

作者：

Lim, Eun-Ju ^{[1
]}

Kang, Hyun-Jung ^{[2
,3
]}

Jung, Hyun-Joo ^{[1
]}

Song, Seon ^{[1
]}

Lim, Chang-Jin ^{[2
,3
]}

Park, Eun-Hee ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

[2] Kangwon Natl Univ, Div Life Sci, Chunchon 200701, South Korea

[3] Kangwon Natl Univ, Life Sci Res Inst, Chunchon 200701, South Korea

来源：

BIOMOLECULES & THERAPEUTICS | 2008年 / 16卷 / 02期

关键词：

vanillin; anti-angiogenic; anti-nociceptive; anti-inflammatory; nitric oxide;

D O I：

10.4062/biomolther.2008.16.2.132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current study aimed to assess some novel pharmacological activities of vanillin. Vanillin inhibited the chick chorioallantoic membrane (CAM) angiogenesis. Vanillin had anti-inflammatory activity using the acetic acid-induced permeability model in mice. Anti-nociceptive activity of vanillin was shown using the acetic acid-induced writhing test in mice. Vanillin inhibited production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) but not cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Vanillin decreased the level of iNOS mRNA in the LPS-activated macrophages. Taken together, these results suggest that vanillin can have anti-angiogenic, anti-inflammatory and anti-nociceptive activities in ICR Mice.

引用

页码：132 / 136

页数：5

共 18 条

[1] Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume [J].

Ahn, Eun-Kyoung ;

Jeon, Hye-Jin ;

Lim, Eun-Ju ;

Jung, Hyun-Joo ;

Park, Eun-Hee .

JOURNAL OF ETHNOPHARMACOLOGY, 2007, 110 (03) :476-482

[2] Determination of the active ingredients in Gastrodia rhizoma by capillary electrophoresis with electrochemical detection [J].

Cao, YH ;

Zhang, X ;

Fang, YZ ;

Ye, JN .

ANALYST, 2001, 126 (09) :1524-1528

[3] REGULATION OF INDUCIBLE NITRIC-OXIDE SYNTHASE MESSENGER-RNA LEVELS BY LPS, INF-GAMMA, TGF-BETA, AND IL-10 IN MURINE MACROPHAGE CELL-LINES AND RAT PERITONEAL-MACROPHAGES [J].

CHESROWN, SE ;

MONNIER, J ;

VISNER, G ;

NICK, HS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (01) :126-134

[4] Role of nitric oxide and reactive oxygen species in arthritis [J].

Cuzzocrea, Salvatore .

CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (27) :3551-3570

[5] Vanillins - a novel family of DNA-PK inhibitors [J].

Durant, S ;

Karran, P .

NUCLEIC ACIDS RESEARCH, 2003, 31 (19) :5501-5512

[6]

FRESHNEY RI, 1994, CULTURE ANIMAL CELLS, P336

[7] Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrasoguanidine and mitomycin C but not 137Cs γ-radiation at the CD59 locus in human-hamster hybrid AL cells [J].

Gustafson, DL ;

Franz, HR ;

Ueno, AM ;

Smith, CJ ;

Doolittle, DJ ;

Waldren, CA .

MUTAGENESIS, 2000, 15 (03) :207-213

[8] Vanillin as an antioxidant in rat liver mitochondria: Inhibition of protein oxidation and lipid peroxidation induced by photosensitization [J].

Kamat, JP ;

Ghosh, A ;

Devasagayam, TPA .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2000, 209 (1-2) :47-53

[9] Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia [J].

Kim, Hyeon Ju ;

Hwang, In Koo ;

Won, Moo Ho .

BRAIN RESEARCH, 2007, 1181 :130-141

[10] Inhibition of peroxynitrite-mediated reactions by vanillin [J].

Kumar, SS ;

Priyadarsini, KI ;

Sainis, KB .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (01) :139-145

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