Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillin in ICR mice

被引:28
作者
Lim, Eun-Ju [1 ]
Kang, Hyun-Jung [2 ,3 ]
Jung, Hyun-Joo [1 ]
Song, Seon [1 ]
Lim, Chang-Jin [2 ,3 ]
Park, Eun-Hee [1 ]
机构
[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea
[2] Kangwon Natl Univ, Div Life Sci, Chunchon 200701, South Korea
[3] Kangwon Natl Univ, Life Sci Res Inst, Chunchon 200701, South Korea
关键词
vanillin; anti-angiogenic; anti-nociceptive; anti-inflammatory; nitric oxide;
D O I
10.4062/biomolther.2008.16.2.132
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The current study aimed to assess some novel pharmacological activities of vanillin. Vanillin inhibited the chick chorioallantoic membrane (CAM) angiogenesis. Vanillin had anti-inflammatory activity using the acetic acid-induced permeability model in mice. Anti-nociceptive activity of vanillin was shown using the acetic acid-induced writhing test in mice. Vanillin inhibited production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) but not cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Vanillin decreased the level of iNOS mRNA in the LPS-activated macrophages. Taken together, these results suggest that vanillin can have anti-angiogenic, anti-inflammatory and anti-nociceptive activities in ICR Mice.
引用
收藏
页码:132 / 136
页数:5
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