Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein

被引：87

作者：

Hanson, CA ^{[1
]}

Miller, JR ^{[1
]}

机构：

[1] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

来源：

GENE | 2005年 / 361卷

关键词：

colon cancer; cell migration; cell adhesion; chromosome instability; Wnt;

D O I：

10.1016/j.gene.2005.07.024

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Adenomatous Polyposis Coli (APC) tumor suppressor is a multifunctional protein that is mutated in a majority of colon cancers. The role of APC as an antagonist of the Wnt signaling pathway is well known and it is widely accepted that inappropriate activation of this pathway through loss of APC function contributes to the progression of colon cancers. However, a body of evidence is growing to support the idea that APC plays non-traditional functions outside of the Wnt pathway with roles in cell migration, adhesion, chromosome segregation, spindle assembly, apoptosis, and neuronal differentiation. This review highlights the research into alternate functions for APC beyond its role in Writ signaling and discusses the possible contributions for these non-traditional functions of APC in tumor formation. (c) 2005 Elsevier B.V All rights reserved.

引用

页码：1 / 12

页数：12

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