New esters of R-(+)-usnic acid

被引：20
|
作者：
Erba, E
Pocar, D
Rossi, LM
机构：
[1] Univ Milan, Fac Farm, Ist Chim Organ, I-20133 Milan, Italy
[2] Univ Milan, Ctr Interuniv Ric Reaz Pericicl & Sintesi Sistemi, I-20133 Milan, Italy
来源：
FARMACO | 1998年 / 53卷 / 10-11期
关键词：
usnic acid; usnic acid esters; antibiotic activity;
D O I：
10.1016/S0014-827X(98)00113-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
By reacting R-(+)-usnic acid (1) with propionic anhydride and chloroacetyl chloride and pyridine the corresponding diesters at the 8-OH and 9-OH groups (2b and c, respectively) were obtained. On reaction of compound 1 with aroyl chlorides and pyridine, the esterification occurred on OH-3 and on the enol form of the acetyl group at C-2 yielding the diesters 3a,c. A tetrabenzoate (4a) and a diacetate-dibenzoate (4b) of compound 1 were also produced. (C) 1998 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：718 / 720
页数：3
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