MiRNA-based therapeutic intervention of cancer

被引：117
作者：
Naidu, Srivatsava [1 ]
Magee, Peter [1 ]
Garofalo, Michela [1 ]
机构：
[1] Univ Manchester, Canc Res UK Manchester Inst, Transcript Networks Lung Canc Grp, Manchester M20 4BX, Lancs, England
来源：
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2015年 / 8卷
关键词：
Noncoding RNAs; Cancer therapy; POTENTIAL TUMOR-SUPPRESSOR; CELL-PROLIFERATION; PROSTATE-CANCER; DOWN-REGULATION; DECREASED EXPRESSION; RNA-INTERFERENCE; UP-REGULATION; MICRORNA; DELIVERY; GROWTH;
D O I：
10.1186/s13045-015-0162-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs.
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页数：8
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