Shaping sound in space: the regulation of inner ear patterning

被引：183

作者：

Groves, Andrew K. ^{[1
,2
,3
]}

Fekete, Donna M. ^{[4
,5
]}

机构：

[1] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[3] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

[4] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA

[5] Purdue Univ, Ctr Canc Res, W Lafayette, IN 47907 USA

来源：

DEVELOPMENT | 2012年 / 139卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Otic placode; Morphogen; Inner ear; Cochlea; Otocyst; PLANAR CELL POLARITY; SONIC HEDGEHOG; RETINOIC ACID; OTIC PLACODE; NEURAL-TUBE; FOREBRAIN DEVELOPMENT; AXIAL SPECIFICATION; FATE SPECIFICATION; ORGAN DEVELOPMENT; FGF;

D O I：

10.1242/dev.067074

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing a group of mechanosensitive sensory organs that mediate hearing and balance. These organs are arranged precisely in space and contain intricately patterned sensory epithelia. Here, we review recent studies of inner ear development and patterning which reveal that multiple stages of ear development - ranging from its early induction from the embryonic ectoderm to the establishment of the three cardinal axes and the fine-grained arrangement of sensory cells - are orchestrated by gradients of signaling molecules.

引用

页码：245 / 257

页数：13

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