The synthesis of isoxazolo[2,3-c]quinazolines via a cycloaddition of quinazoline-3-oxides and acrylates

被引：4
|
作者：
Yin, Zhijian [1 ,2 ]
Li, Xinyi [1 ,2 ]
Deng, Zhihong [1 ,2 ]
Yang, Qin [1 ,2 ]
Peng, Yiyuan [1 ,2 ]
机构：
[1] Minist Educ, Key Lab Funct Small Organ Mol, Jiangxi Prov Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China
[2] Jiangxi Normal Univ, Nanchang 330022, Jiangxi, Peoples R China
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 18期
基金：
中国国家自然科学基金;
关键词：
Cycloaddition; Isoxazolo[2,3-c]quinazoline; Quinazoline-3-oxide; Acrylate; 1,3-DIPOLAR CYCLOADDITION; DIPOLAR DERIVATIVES; 2,4-DIARYLQUINAZOLINES; REAGENTS; NITRONES; SERIES;
D O I：
10.1016/j.tetlet.2020.151818
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A variety of isoxazolo[2,3-c]quinazolines were synthesized via a [3 + 2] cycloaddition of quinazoline-3-oxides with acrylates. The reaction exhibits a broad substrate scope and good functional group tolerance. The corresponding isoxazolo[2,3-c]quinazolines can be obtained in good to excellent yields in 1,4-dioxane. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：5
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