Detergent-Free Formation and Physicochemical Characterization of Nanosized Lipid-Polymer Complexes: Lipodisq

被引：147
|
作者：
Orwick, Marcella C. [1 ]
Judge, Peter J. [1 ]
Procek, Jan [2 ]
Lindholm, Ljubica [3 ]
Graziadei, Andrea [1 ]
Engel, Andreas [5 ]
Grobner, Gerhard [4 ]
Watts, Anthony [1 ]
机构：
[1] Univ Oxford, Dept Biochem, Biomembrane Struct Unit, Oxford OX1 3QU, England
[2] Wroclaw Univ Technol, Inst Biomed Engn & Instrumentat, PL-50370 Wroclaw, Poland
[3] Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden
[4] Umea Univ, Dept Chem, S-9087 Umea, Sweden
[5] Univ Basel, Biozentrum, ME Muller Inst Struct Biol, Basel, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 19期
基金：
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
calorimetry; EPR spectroscopy; lipids; membranes; polymers; HIGH-DENSITY-LIPOPROTEINS; MEMBRANE-PROTEINS; PHASE-TRANSITIONS; BILAYER; FLUORESCENCE; INTACT;
D O I：
10.1002/anie.201201355
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Lipodisq particles are polymer-lipid complexes formed by detergent-free methods. Lipodisq particles containing dimyristoylphosphatidylcholine (DMPC) are characterized by increased lipid ordering compared to a DMPC dispersion. The styrene and maleic acid groups of the polymer interact with the DMPC lipid chains in bilayers, as well as lipid headgroups in the Lipodisq periphery (see picture). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4653 / 4657
页数：5
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