What is the impact of SARS-CoV-2 pandemic on antimicrobial stewardship programs (ASPs)? The results of a survey among a regional network of infectious disease centres

被引：17

作者：

Comelli, Agnese ^{[1
]}

Genovese, Camilla ^{[2
]}

Lombardi, Andrea ^{[1
,2
]}

Bobbio, Chiara ^{[1
]}

Scudeller, Luigia ^{[3
]}

Restelli, Umberto ^{[4
]}

Muscatello, Antonio ^{[1
]}

Antinori, Spinello ^{[5
]}

Bonfanti, Paolo ^{[6
]}

Casari, Salvatore ^{[7
]}

Castagna, Antonella ^{[8
]}

Castelli, Francesco ^{[9
,10
]}

Monforte, Antonella d'Arminio ^{[11
]}

Franzetti, Fabio ^{[12
]}

Grossi, Paolo ^{[13
,14
]}

Lupi, Matteo ^{[15
]}

Morelli, Paola ^{[16
]}

Piconi, Stefania ^{[17
]}

Puoti, Massimo ^{[18
]}

Pusterla, Luigi ^{[19
]}

Regazzetti, Angelo ^{[20
]}

Rizzi, Marco ^{[21
]}

Rusconi, Stefano ^{[22
]}

Zuccaro, Valentina ^{[23
]}

Gori, Andrea ^{[1
,2
]}

Bandera, Alessandra ^{[1
,2
]}

机构：

[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Infect Dis Unit, Via Francesco Sforza 35, I-20122 Milan, Italy

[2] Univ Milan, Milan, Italy

[3] IRCCS Azienda Osped Univ Bologna, Res & Innovat Unit, Bologna, Italy

[4] LIUC Cattaneo Univ, Castellanza, VA, Italy

[5] Univ Milan, Dept Biomed & Clin Sci DIBIC, Milan, Italy

[6] Univ Milano Bicocca, San Gerardo Hosp, Infect Dis Unit, Monza, Italy

[7] Carlo Poma Hosp, Unit Infect Dis, ASST Mantova, Mantua, Italy

[8] IRCCS San Raffaele Sci Inst, Infect Dis Unit, Milan, Italy

[9] Univ Brescia, Univ Dept Infect & Trop Dis, Brescia, Italy

[10] ASST Spedali Civili, Brescia, Italy

[11] Univ Milan, Dept Hlth Sci, Clin Infect Dis, ASST Santi Paolo & Carlo, Milan, Italy

[12] Busto Arsizio Hosp, Infect Dis Unit, ASST Valle Olona, Busto Arsizio, Italy

[13] Univ Insubria, Dept Med & Surg, Infect & Trop Dis Unit, Varese, Italy

[14] ASST Sette Laghi, Varese, Italy

[15] ASST Cremona, Div Infect Dis, Cremona, Italy

[16] IRCCS Humanitas Res Hosp, Infect Dis Unit, Rozzano, Italy

[17] Alessandro Manzoni Hosp, Infect Dis Unit, ASST Lecco, Lecce, Italy

[18] Hosp Niguarda, Infect Dis, Milan, Italy

[19] ASST Lariana, Div Infect Dis, Como, Italy

[20] ASST Lodi, UOC Malattie Infett & Tropicali, Osped Delmati St Angelo Lodigiano, Lodi, Italy

[21] ASST Papa Giovanni XXIII, Infect Dis Unit, Bergamo, Italy

[22] ASST Ovest Milanese, Infect Dis Unit, Osped Civile Legnano, Legnano, Italy

[23] Fdn IRCCS Policlin San Matteo, Div Infect Dis 1, Pavia, Italy

来源：

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL | 2022年 / 11卷 / 01期

关键词：

COVID-19; SARS-CoV-2; Antimicrobial stewardship; Multidrug resistant organisms; Antimicrobials use;

D O I：

10.1186/s13756-022-01152-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Discontinuation of antimicrobial stewardship programs (ASPs) and increased antibiotic use were described during SARS-CoV-2 pandemic. In order to measure COVID-19 impact on ASPs in a setting of high multidrug resistance organisms (MDRO) prevalence, a qualitative survey was designed. In July 2021, eighteen ID Units were asked to answer a questionnaire about their hospital characteristics, ASPs implementation status before the pandemic and impact of SARS-CoV-2 pandemic on ASPs after the 1st and 2nd pandemic waves in Italy. Nine ID centres (50%) reported a reduction of ASPs and in 7 cases (38.9%) these were suspended. After the early pandemic waves, the proportion of centres that restarted their ASPs was higher among the ID centres where antimicrobial stewardship was formally identified as a priority objective (9/11, 82%, vs 2/7, 28%). SARS-CoV-2 pandemic had a severe impact in ASPs in a region highly affected by COVID-19 and antimicrobial resistance but weaknesses related to the pre-existent ASPs might have played a role.

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