Use of right orbitofrontal repetitive transcranial magnetic stimulation (rTMS) augmentation for treatment-refractory obsessive-compulsive disorder with comorbid major depressive disorder

被引：11

作者：

Tadayonnejad, Reza ^{[1
,2
,4
]}

Wilson, Andrew C. ^{[1
,2
]}

Chu, Stephanie Anne ^{[1
,2
]}

Corlier, Juliana ^{[1
,2
]}

Citrenbaum, Cole ^{[1
,2
]}

Ngo, Thuc Doan P. ^{[1
,2
]}

Hovhannisyan, Emmily ^{[1
,2
]}

Ginder, Nathaniel D. ^{[1
,2
]}

Levitt, Jennifer G. ^{[1
,2
]}

Wilke, Scott A. ^{[1
,2
]}

Krantz, David ^{[1
,2
]}

Bari, Ausaf A. ^{[3
]}

Leuchter, Andrew F. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, TMS Clin & Res Serv, Neuromodulat Div, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA

[2] Dept Psychiat & Biobehav Sci, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA USA

[4] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA

来源：

PSYCHIATRY RESEARCH | 2022年 / 317卷

关键词：

Comorbid OCD-MDD; rTMS; Orbitofrontal cortex;

D O I：

10.1016/j.psychres.2022.114856

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We examined the safety and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) of the right orbi-tofrontal cortex (OFC) in patients with refractory obsessive-compulsive disorder (OCD) and comorbid Major Depressive Disorder. All participants (n = 26) received excitatory stimulation of the left dorsolateral prefrontal cortex followed by inhibitory stimulation of bilateral supplementary motor area for 10 sessions. In 18 patients with poor early OCD response, treatment was augmented with OFC inhibitory stimulation after the tenth treatment session. Augmentation with OFC stimulation was well-tolerated, and associated with further allevia-tion of both OCD and depression symptoms, particularly in individuals with more severe illnesses.

引用

页数：4

共 25 条

[1] The prefrontal cortex and OCD [J].

Ahmari, Susanne E. ;

Rauch, Scott L. .

NEUROPSYCHOPHARMACOLOGY, 2022, 47 (01) :211-224

[2]

BAXTER LR, 1987, ARCH GEN PSYCHIAT, V44, P211

[3] Neuroscientifically Informed Formulation and Treatment Planning for Patients With Obsessive-Compulsive Disorder A Review [J].

Dougherty, Darin D. ;

Brennan, Brian P. ;

Stewart, S. Evelyn ;

Wilhelm, Sabine ;

Widge, Alik S. ;

Rauch, Scott L. .

JAMA PSYCHIATRY, 2018, 75 (10) :1081-1087

[4] 1 Hz rTMS of the right orbitofrontal cortex for major depression: Safety, tolerability and clinical outcomes [J].

Feffer, Kfir ;

Fettes, Peter ;

Giacobbe, Peter ;

Daskalakis, Zafiris J. ;

Blumberger, Daniel M. ;

Downar, Jonathan .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2018, 28 (01) :109-117

[5] Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder [J].

Goodman, Wayne K. ;

Storch, Eric A. ;

Sheth, Sameer A. .

AMERICAN JOURNAL OF PSYCHIATRY, 2021, 178 (01) :17-29

[6]

GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006

[7] High-frequency stimulation of deep brain structures in obsessive-compulsive disorder: the search for a valid circuit [J].

Haynes, William I. A. ;

Mallet, Luc .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2010, 32 (07) :1118-1127

[8] Efficacy and tolerability of repetitive transcranial magnetic stimulation for the treatment of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis [J].

Liang, Kaili ;

Li, Hailong ;

Bu, Xuan ;

Li, Xue ;

Cao, Lingxiao ;

Liu, Jing ;

Gao, Yingxue ;

Li, Bin ;

Qiu, Changjian ;

Bao, Weijie ;

Zhang, Suming ;

Hu, Xinyu ;

Xing, Haoyang ;

Gong, Qiyong ;

Huang, Xiaoqi .

TRANSLATIONAL PSYCHIATRY, 2021, 11 (01)

[9] Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder [J].

Mantovani, Antonio ;

Simpson, Helen B. ;

Fallon, Brian A. ;

Rossi, Simone ;

Lisanby, Sarah H. .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2010, 13 (02) :217-227

[10] Repetitive transcranial magnetic stimulation over the orbitofrontal cortex for obsessive-compulsive disorder: a double-blind, crossover study [J].

Nauczyciel, C. ;

Le Jeune, F. ;

Naudet, F. ;

Douabin, S. ;

Esquevin, A. ;

Verin, M. ;

Dondaine, T. ;

Robert, G. ;

Drapier, D. ;

Millet, B. .

TRANSLATIONAL PSYCHIATRY, 2014, 4 :e436-e436

← 1 2 3 →