Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

被引：79

作者：

Duell, Eric J. ^{[1
]}

Travier, Noemie ^{[1
]}

Lujan-Barroso, Leila ^{[1
]}

Clavel-Chapelon, Francoise ^{[2
]}

Boutron-Ruault, Marie-Christine ^{[2
]}

Morois, Sophie ^{[2
]}

Palli, Domenico ^{[3
]}

Krogh, Vittorio ^{[4
]}

Panico, Salvatore ^{[5
]}

Tumino, Rosario ^{[6
,7
]}

Sacerdote, Carlotta ^{[8
]}

Ramon Quiros, J. ^{[9
]}

Sanchez-Cantalejo, Emilio ^{[12
,13
]}

Navarro, Carmen ^{[10
]}

Barricarte Gurrea, Aurelio ^{[11
]}

Dorronsoro, Miren ^{[14
]}

Khaw, Kay-Tee ^{[15
]}

Allen, Naomi E. ^{[16
]}

Key, Timothy J. ^{[16
]}

Bueno-de-Mesquita, H. Bas ^{[17
,18
]}

Ros, Martine M. ^{[19
]}

Numans, Mattijs E. ^{[20
]}

Peeters, Petra H. M. ^{[20
]}

Trichopoulou, Antonia

Naska, Androniki ^{[21
]}

Dilis, Vardis ^{[21
,22
]}

Teucher, Birgit ^{[23
]}

Kaaks, Rudolf ^{[23
]}

Boeing, Heiner ^{[24
]}

Schuetze, Madlen ^{[24
]}

Regner, Sara ^{[25
]}

Lindkvist, Bjoern ^{[25
]}

Johansson, Ingegerd ^{[26
]}

Hallmans, Goran ^{[27
]}

Overvad, Kim ^{[29
]}

Egeberg, Rikke ^{[30
]}

Tjonneland, Anne

Lund, Eiliv ^{[31
]}

Weiderpass, Elisabete ^{[31
,32
,33
,34
]}

Braaten, Tonje ^{[31
]}

Romieu, Isabelle ^{[35
]}

Ferrari, Pietro ^{[35
]}

Jenab, Mazda ^{[35
]}

Stenling, Roger ^{[28
]}

Aune, Dagfinn ^{[36
]}

Norat, Teresa ^{[36
]}

Riboli, Elio ^{[36
]}

Gonzalez, Carlos A. ^{[1
]}

机构：

[1] Catalan Inst Oncol, Bellvitge Biomed Res Inst IDIBELL, Unit Nutr Environm & Canc, Barcelona 08907, Spain

[2] Paris S Univ, Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, INSERM, Villejuif, France

[3] Canc Res & Prevent Inst ISPO, Mol & Nutrit Epidemiol Unit, Florence, Italy

[4] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[5] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[6] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[7] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[8] Human Genet Fdn HuGeF, Ctr Canc Prevent CPO Piemonte, Turin, Italy

[9] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[10] CIBERESP, Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[11] CIBERESP, Consortium Biomed Res Epidemiol & Publ Hlth, Navarra Publ Hlth Inst, Pamplona, Spain

[12] Andalusian Sch Publ Hlth, Granada, Spain

[13] CIBERESP, Granada, Spain

[14] CIBERESP, Basque Reg Hlth Dept, Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[15] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[16] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[17] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[18] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[19] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, Natl Inst Publ Hlth & Environm RIVM, NL-6525 ED Nijmegen, Netherlands

[20] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[21] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[22] Hellen Hlth Fdn, Athens, Greece

[23] German Canc Res Ctr, D-6900 Heidelberg, Germany

[24] German Inst Human Nutr, Dept Epidemiol, Nuthetal, Germany

[25] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden

[26] Umea Univ, Dept Odontol, Umea, Sweden

[27] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[28] Umea Univ, Dept Med Biosci, Umea, Sweden

[29] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[30] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[31] Univ Tromso, Dept Community Med, Tromso, Norway

[32] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[33] Canc Registry Norway, Dept Etiol Res, Oslo, Norway

[34] Univ Helsinki, Folkhalsan Res Ctr, Dept Genet Epidemiol, FIN-00014 Helsinki, Finland

[35] Int Agcy Res Canc, IARC WHO, F-69372 Lyon, France

[36] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2011年 / 94卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

N-NITROSO COMPOUNDS; STOMACH-CANCER; EPIDEMIOLOGY; NITROSAMINES; BEVERAGES; DRINKING; VALIDITY; ETHANOL; SMOKING; NITRITE;

D O I：

10.3945/ajcn.111.012351

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Gastric cancer (GC) is the second leading cause of cancer death worldwide. The association between alcohol consumption and GC has been investigated in numerous epidemiologic studies with inconsistent results. Objective: We evaluated the association between alcohol consumption and GC risk. Design: We conducted a prospective analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 444 cases of first primary gastric adenocarcinoma. HRs and 95% CIs for GC were estimated by using multivariable Cox proportional hazards regression for consumption of pure ethanol in grams per day, with stratification by smoking status, anatomic subsite (cardia, noncardia), and histologic subtype (diffuse, intestinal). In a subset of participants, results were further adjusted for baseline Helicobacter pylori serostatus. Results: Heavy (compared with very light) alcohol consumption (>= 60 compared with 0.1-4.9 g/d) at baseline was positively associated with GC risk (HR: 1.65; 95% CI: 1.06, 2.58), whereas lower consumption amounts (<60 g/d) were not. When we analyzed GC risk by type of alcoholic beverage, there was a positive association for beer (>= 30 g/d; HR: 1.75; 95% CI: 1.13, 2.73) but not for wine or liquor. Associations were primarily observed at the highest amounts of drinking in men and limited to noncardia subsite and intestinal histology; no statistically significant linear dose-response trends with GC risk were observed. Conclusion: Heavy (but not light or moderate) consumption of alcohol at baseline (mainly from beer) is associated with intestinal-type noncardia GC risk in men from the EPIC cohort. Am J Clin Nutr 2011;94:1266-75.

引用

页码：1266 / 1275

页数：10

共 35 条

[1] Carcinogenicity of alcoholic beverages [J].

Baan, Robert ;

Straif, Kurt ;

Grosse, Yann ;

Secretan, Beatrice ;

El Ghissassi, Fatiha ;

Bouvard, Veronique ;

Altieri, Andrea ;

Cogliano, Vincent .

LANCET ONCOLOGY, 2007, 8 (04) :292-293

[2] CASE-CONTROL STUDY ON STOMACH-CANCER IN GERMANY [J].

BOEING, H ;

FRENTZELBEYME, R ;

BERGER, M ;

BERNDT, V ;

GORES, W ;

KORNER, M ;

LOHMEIER, R ;

MENARCHER, A ;

MANNL, HFK ;

MEINHARDT, M ;

MULLER, R ;

OSTERMEIER, H ;

PAUL, F ;

SCHWEMMLE, K ;

WAGNER, KH ;

WAHRENDORF, J .

INTERNATIONAL JOURNAL OF CANCER, 1991, 47 (06) :858-864

[3] Pathology findings and validation of gastric and esophageal cancer cases in a European cohort (EPIC/EUR-GAST) [J].

Carneiro, Fatima ;

Moutinho, Catia ;

Pera, Guillem ;

Caldas, Carlos ;

Fenger, Claus ;

Offerhaus, Johan ;

Save, Vicki ;

Stenling, Roger ;

Nesi, Gabriella ;

Mahlke, U. ;

Blaeker, Hendrik ;

Torrado, Julio ;

Roukos, Dimitrios H. ;

Sabourin, Jean-Christophe ;

Boeing, Heiner ;

Palli, Domenico ;

Bueno-De-Mesquita, H. Bas ;

Overvad, Kim ;

Bingham, Sheila ;

Clavel-Chapelon, Francoise ;

Lund, Eiliv ;

Trichopoulou, Antonia ;

Manjer, Jonas ;

Riboli, Elio ;

Gonzalez, Carlos A. .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2007, 42 (05) :618-627

[4] Tobacco smoking and alcohol drinking as risk factors for stomach cancer: a case-control study in Uruguay [J].

De Stefani, E ;

Boffetta, P ;

Carzoglio, J ;

Mendilaharsu, S ;

Deneo-Pellegrini, H .

CANCER CAUSES & CONTROL, 1998, 9 (03) :321-329

[5] Dietary nitrosamines, heterocyclic amines, and risk of gastric cancer: A case-control study in Uruguay [J].

De Stefani, E ;

Boffetta, P ;

Mendilaharsu, M ;

Carzoglio, J ;

Deneo-Pellegrini, H .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1998, 30 (02) :158-162

[6]

Friday JE., 2006, MyPyramid Equivalents Database for USDA Survey Food Codes

[7] Intakes of selected foods and beverages and the incidence of gastric cancer among the Japanese residents of Hawaii: a prospective study [J].

Galanis, DJ ;

Kolonel, LN ;

Lee, J ;

Nomura, A .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1998, 27 (02) :173-180

[8] Meat intake and risk of stomach and Esophageal adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) [J].

González, CA ;

Jakszyn, P ;

Pera, G ;

Agudo, A ;

Bingham, S ;

Palli, D ;

Ferrari, P ;

Boeing, H ;

del Giudice, G ;

Plebani, M ;

Carneiro, F ;

Nesi, G ;

Berrino, F ;

Sacerdote, C ;

Tumino, R ;

Panico, S ;

Berglund, G ;

Simán, H ;

Nyrén, O ;

Hallmans, G ;

Martinez, C ;

Dorronsoro, M ;

Barricarte, A ;

Navarro, C ;

Quirós, JR ;

Allen, N ;

Key, TJ ;

Day, NE ;

Linseisen, J ;

Nagel, G ;

Bergmann, MM ;

Overvad, K ;

Jensen, MK ;

Tjonneland, A ;

Olsen, A ;

Bueno-De-Mesquita, HB ;

Ocke, M ;

Peeters, PHM ;

Numans, ME ;

Clavel-Chapelon, F ;

Boutron-Ruault, MC ;

Trichopoulou, A ;

Psaltopoulou, T ;

Roukos, D ;

Lund, E ;

Hemon, B ;

Kaaks, R ;

Norat, T ;

Riboli, E .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (05) :345-354

[9]

Harrell FE., 2001, Regression Modeling Strategies: with Applications to Linear Models, Logistic Regression, and Survival Analysis, V608, DOI DOI 10.2147/

[10]

Hashibe M, 2008, JNCI-J NATL CANCER I, V100, P225

← 1 2 3 4 →