Decreasing Rate of Biliary Atresia in Taiwan: A Survey, 2004-2009

被引：45

作者：

Lin, Yi-Chun ^{[1
]}

Chang, Mei-Hwei ^{[1
,2
]}

Liao, Shu-Fen ^{[3
]}

Wu, Jia-Feng ^{[1
]}

Ni, Yen-Hsuan ^{[1
]}

Tiao, Mao-Meng ^{[4
,5
]}

Lai, Ming-Wei ^{[6
]}

Lee, Hung-Chang ^{[7
]}

Lin, Chieh-Chung ^{[8
]}

Wu, Tzee-Chung ^{[9
,10
]}

Lau, Beng-Huat ^{[12
]}

Tsai, Tong-Chi ^{[13
]}

Yang, Yao-Jong ^{[14
]}

Chen, An-Chyi ^{[15
]}

Shih, Hsiang-Hung ^{[16
,17
]}

Lee, I-Hsien ^{[18
]}

Lee, Wen-Chung ^{[2
,3
]}

Chen, Huey-Ling ^{[1
]}

Hsu, Hong-Yuan ^{[1
]}

Chiou, Shu-Ti ^{[11
,19
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Pediat, Taipei, Taiwan

[2] Natl Taiwan Univ, Res Ctr Genes Environm & Human Hlth, Taipei 10764, Taiwan

[3] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei 10764, Taiwan

[4] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Pediat, Kaohsiung, Taiwan

[5] Chang Gung Univ, Coll Med, Dept Pediat, Kaohsiung, Taiwan

[6] Chang Gung Mem Hosp, Dept Pediat, Tao Yuan, Taiwan

[7] Mackay Mem Hosp, Dept Pediat, Taipei, Taiwan

[8] Taichung Vet Gen Hosp, Dept Pediat, Taichung, Taiwan

[9] Taichung Vet Gen Hosp, Dept Pediat, Taipei, Taiwan

[10] Natl Yang Ming Univ, Dept Med, Taipei 112, Taiwan

[11] Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan

[12] Shin Kong Wu Ho Su Mem Hosp, Dept Pediat, Taipei, Taiwan

[13] St Josephs Hosp, Dept Pediat, Huwei, Taiwan

[14] Natl Cheng Kung Univ Hosp, Dept Pediat, Tainan 70428, Taiwan

[15] China Med Univ Hosp, Dept Pediat, Taichung, Taiwan

[16] Kaohsiung Med Univ Hosp, Dept Pediat, Kaohsiung, Taiwan

[17] Kaohsiung Municipal Hsiaokang Hosp, Dept Pediat, Kaohsiung, Taiwan

[18] Chi Mei Med Ctr, Dept Pediat, Tainan, Taiwan

[19] Bureau Hlth Promot, Dept Hlth, Taipei, Taiwan

来源：

PEDIATRICS | 2011年 / 128卷 / 03期

关键词：

biliary atresia; incidence; epidemiology; rotavirus; gross domestic product; STOOL COLOR CARD; NEWBORN MICE; MURINE MODEL; EPIDEMIOLOGY; VACCINATION; ROTAVIRUS; ETIOLOGY;

D O I：

10.1542/peds.2011-0742

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

OBJECTIVES: The pathogenesis of biliary atresia (BA) is unclear, but epidemiological studies may help to elucidate possible causes. The goals of this study were to identify BA incidence changes in Taiwan in 2004-2009 and to survey the factors that might influence incidence changes to elucidate the possible causes of BA. METHODS: A Taiwan national registry system for BA has been established since 2004. By using data from the national registry system for BA, we identified BA incidence changes in 2004-2009. We also evaluated the correlations between BA incidences and estimated rotavirus vaccine coverage rates and between BA incidences and the gross domestic product. RESULTS: A total of 185 patients with BA were identified in 2004-2009 in Taiwan, whereas the number of live births was 1 221 189. Compared with the incidence of BA in 2004-2006 (1.79 cases per 10 000 live births), the incidence of BA in 2007-2009 (1.23 cases per 10 000 live births) was decreased significantly (P = .01). BA incidences were negatively correlated with the gross domestic product (P = .02) and marginally negatively correlated with rotavirus vaccine coverage rates (P = .07). CONCLUSIONS: A significant decrease in BA incidence in Taiwan since 2007 has been noted and may be related to improvements in the general socioeconomic status and the popularity of rotavirus vaccination. Although more evidence is needed to establish a direct correlation, this phenomenon may shed light on possible causes of and preventive interventions for BA. Pediatrics 2011; 128: e530-e536

引用

页码：E530 / E536

页数：7

共 35 条

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