Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

被引：18

作者：

Acosta, Matias ^{[1
]}

Detsch, Rainer ^{[2
]}

Gruenewald, Alina ^{[2
]}

Rojas, Virginia ^{[1
]}

Schultheiss, Jan ^{[1
]}

Wajda, Aleksandra ^{[3
]}

Stark, Robert W. ^{[4
,5
]}

Narayan, Suman ^{[4
,5
]}

Sitarz, Maciej ^{[3
]}

Koruza, Jurij ^{[1
]}

Boccaccini, Aldo R. ^{[2
]}

机构：

[1] Tech Univ Darmstadt, Dept Geo & Mat Sci, Inst Mat Sci, Darmstadt, Germany

[2] Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Erlangen, Germany

[3] AGH Univ Sci & Technol, Fac Mat Sci & Ceram, Krakow, Poland

[4] Tech Univ Darmstadt, Inst Mat Sci, Phys Surfaces, Darmstadt, Germany

[5] Tech Univ Darmstadt, Ctr Smart Interfaces, Darmstadt, Germany

来源：

JOURNAL OF THE AMERICAN CERAMIC SOCIETY | 2018年 / 101卷 / 01期

关键词：

biocompatible materials; cytotoxicity; ferroelectrics; mouse embryonic fibroblasts; piezoelectric materials; FREE PIEZOELECTRIC CERAMICS; LEAD-FREE PIEZOCERAMICS; ELECTROMECHANICAL PROPERTIES; POLARIZED HYDROXYAPATITE; TITANATE CERAMICS; CELL BEHAVIOR; ADHESION; WETTABILITY; TOXICITY; PROLIFERATION;

D O I：

10.1111/jace.15193

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1-x) (Na1/2Bi1/2)TiO3-xBaTiO(3), (1-x)Ba(Zr0.2Ti0.8)O-3-x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O-3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3-0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 +/- 30)% and DNA synthesis of (299 +/- 85)% in comparison to the reference. Lead leaching from Pb(Zr,Ti)O-3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.

引用

页码：440 / 449

页数：10

共 60 条

[1] Relationship between electromechanical properties and phase diagram in the Ba(Zr0.2Ti0.8)O3-x(Ba0.7Ca0.3)TiO3 lead-free piezoceramic [J].