The Multifarious Hippocampal Functions of MicroRNA-137

被引：9

作者：

Kos, Aron ^{[1
,2
]}

Aschrafi, Armaz ^{[1
,2
]}

Kasri, Nael Nadif ^{[1
,2
,3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands

[2] Donders Inst Brain Cognit & Behav, Ctr Neurosci, Geert Grootepl 21, NL-6525 AJ Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

来源：

NEUROSCIENTIST | 2016年 / 22卷 / 05期

关键词：

schizophrenia; intellectual disability; noncoding RNA; epigenetics; trisynaptic loop; glutamatergic neurons; neurotransmission; MENTAL-RETARDATION PROTEIN; GENE ZNF804A; SCHIZOPHRENIA; EXPRESSION; MATURATION; MIR-137; MEMORY; RISK; DYSREGULATION; MECHANISMS;

D O I：

10.1177/1073858415608356

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

MicroRNAs (miRs) have emerged as a powerful class of endogenous noncoding RNAs involved in posttranscriptional gene expression regulation. miR-137 has repeatedly been associated with schizophrenia and intellectual disability. Recent studies describe the mechanisms of miR-137 in mediating basic synaptic transmission and plasticity in the hippocampus. A picture is emerging in which miR-137 acts as a potent player in regulating glutamatergic synaptic transmission in the hippocampus by controlling the translation of functionally critical genes at spatially opposite ends of the synapse, contributing to the pathogenesis of cognitive impairments as seen in neurodevelopmental disorders.

引用

页码：440 / 446

页数：7

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