Functionalizing Framework Nucleic-Acid-Based Nanostructures for Biomedical Application

被引:246
作者
Zhang, Tao [1 ]
Tian, Taoran [1 ]
Lin, Yunfeng [2 ,3 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China
[3] Sichuan Univ, Coll Biomed Engn, Chengdu 610041, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
antibacterial therapy; anticancer therapy; drug delivery; dynamic DNA structure; ROS scavenging; tetrahedral framework nucleic acids; tissue engineering; TETRAHEDRAL DNA NANOSTRUCTURES; ROLLING CIRCLE AMPLIFICATION; ORIGAMI NANOSTRUCTURES; I-MOTIF; OXIDATIVE STRESS; DRUG-DELIVERY; G-QUADRUPLEX; PROTEIN; RNA; ENCAPSULATION;
D O I
10.1002/adma.202107820
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been extensively explored since the first successful fabrication of tFNA by Turberfield. One-pot annealing of at least four DNA single strands is the most common method to prepare tFNA, as it optimizes the cost, yield, and speed of assembly. Herein, the focus is on four key merits of tFNAs and their potential for biomedical applications. The natural ability of tFNA to scavenge reactive oxygen species, along with remarkable enhancement in cellular endocytosis and tissue permeability based on its appropriate size and geometry, promotes cell-material interactions to direct or probe cell behavior, especially to treat inflammatory and degenerative diseases. Moreover, the structural programmability of tFNA enables the development of static tFNA-based nanomaterials via engineering of functional oligonucleotides or therapeutic molecules, and dynamic tFNAs via attachment of stimuli-responsive DNA apparatuses, leading to potential applications in targeted therapies, tissue regeneration, antitumor strategies, and antibacterial treatment. Although there are impressive performance and significant progress, the challenges and prospects of functionalizing tFNA-based nanostructures are still indicated in this review.
引用
收藏
页数:28
相关论文
共 187 条
[1]   Redox-dependent control of i-Motif DNA structure using copper cations [J].
Abdelhamid, Mahmoud A. S. ;
Fabian, Laszlo ;
MacDonald, Colin J. ;
Cheesman, Myles R. ;
Gates, Andrew J. ;
Waller, Zoe A. E. .
NUCLEIC ACIDS RESEARCH, 2018, 46 (12) :5886-5893
[2]   i-Motif DNA: structural features and significance to cell biology [J].
Abou Assi, Hala ;
Garavis, Miguel ;
Gonzalez, Carlos ;
Damha, Masad J. .
NUCLEIC ACIDS RESEARCH, 2018, 46 (16) :8038-8056
[3]   Review on the binding of anticancer drug doxorubicin with DNA and tRNA: Structural models and antitumor activity [J].
Agudelo, D. ;
Bourassa, P. ;
Berube, G. ;
Tajmir-Riahi, H. A. .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2016, 158 :274-279
[4]   (Poly)cation-induced protection of conventional and wireframe DNA origami nanostructures [J].
Ahmadi, Yasaman ;
De Llano, Elisa ;
Barisic, Ivan .
NANOSCALE, 2018, 10 (16) :7494-7504
[5]   Engineering Cell Surface Function with DNA Origami [J].
Akbari, Ehsan ;
Mollica, Molly Y. ;
Lucas, Christopher R. ;
Bushman, Sarah M. ;
Patton, Randy A. ;
Shahhosseini, Melika ;
Song, Jonathan W. ;
Castro, Carlos E. .
ADVANCED MATERIALS, 2017, 29 (46)
[6]   Docking on the DNA G-Quadruplex: A Molecular Electrostatic Potential Study [J].
Antonio Mondragon-Sanchez, Juan ;
Santamaria, Ruben ;
Garduno-Juarez, Ramon .
BIOPOLYMERS, 2011, 95 (09) :641-650
[7]   A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats [J].
Arumugam, TV ;
Shiels, IA ;
Strachan, AJ ;
Abbenante, G ;
Fairlie, DP ;
Taylor, SM .
KIDNEY INTERNATIONAL, 2003, 63 (01) :134-142
[8]   Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape [J].
Bastings, Maartje M. C. ;
Anastassacos, Frances M. ;
Ponnuswamy, Nandhini ;
Leifer, Franziska G. ;
Cuneo, Garry ;
Lin, Chenxiang ;
Ingber, Donald E. ;
Ryu, Ju Hee ;
Shih, William M. .
NANO LETTERS, 2018, 18 (06) :3557-3564
[9]   A synthetic icosahedral DNA-based host-cargo complex for functional in vivo imaging [J].
Bhatia, Dhiraj ;
Surana, Sunaina ;
Chakraborty, Saikat ;
Koushika, Sandhya P. ;
Krishnan, Yamuna .
NATURE COMMUNICATIONS, 2011, 2
[10]   Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure [J].
Boutaud, Olivier ;
Moore, Kevin P. ;
Reeder, Brandon J. ;
Harry, David ;
Howie, Alexander J. ;
Wang, Shuhe ;
Carney, Clare K. ;
Masterson, Tina S. ;
Amin, Taneem ;
Wright, David W. ;
Wilson, Michael T. ;
Oates, John A. ;
Roberts, L. Jackson, II .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (06) :2699-2704