Sustained Response After Remdesivir and Convalescent Plasma Therapy in a B-Cell-Depleted Patient With Protracted Coronavirus Disease 2019 (COVID-19)

被引：30

作者：

Malsy, Jakob ^{[1
,2
]}

Veletzky, Luzia ^{[1
,2
]}

Heide, Janna ^{[1
,2
,3
]}

Hennigs, Annette ^{[1
,2
]}

Gil-Ibanez, Ines ^{[1
,2
]}

Stein, Alexander ^{[4
,5
]}

Lutgehetmann, Marc ^{[3
,6
]}

Rosien, Ulrich ^{[7
]}

Jasper, Dorothea ^{[7
]}

Peine, Sven ^{[8
]}

Hiller, Jens ^{[8
]}

Haag, Friedrich ^{[9
]}

Schmiedel, Stefan ^{[1
,2
]}

Huber, Samuel ^{[1
,2
]}

Jordan, Sabine ^{[1
,2
]}

Addo, Marylyn M. ^{[1
,2
,3
]}

zur Wiesch, Julian Schulze ^{[1
,2
,3
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Sect Infect Dis, Dept Med Gastroenterol & Hepatul, Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Sect Trop Med, Dept Med Gastroenterol & Hepatul, Hamburg, Germany

[3] German Ctr Infect Res DZIF, Hamburg, Germany

[4] Hamatolog Onkol Praxis Eppendorf HOPE, Hamburg, Germany

[5] Univ Canc Ctr Hamburg UCCH, Hamburg, Germany

[6] Univ Med Ctr Hamburg Eppendorf, Inst Med Microbiol, Hamburg, Germany

[7] Israelit Krankenhaus, Dept Med, Hamburg, Germany

[8] Univ Med Ctr Hamburg Eppendorf, Inst Transfus Med, Hamburg, Germany

[9] Univ Med Ctr Hamburg Eppendorf, Dept Clin Immunol, Hamburg, Germany

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 73卷 / 11期

关键词：

COVID-19; obinutuzumab; follicular lymphoma; convalescent plasma; remdesivir; CLINICAL CHARACTERISTICS;

D O I：

10.1093/cid/ciaa1637

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We provide detailed clinical, virological, and immunological data of a B-cell-depleted patient treated with obinutuzumab for follicular lymphoma with protracted coronavirus disease 2019 (COVID-19) and viremia. A sustained response was achieved after 2 courses of remdesivir and subsequent convalescent plasma therapy. Immunocompromised patients might require combined and prolonged antiviral treatment regimens.

引用

页码：E4020 / E4024

页数：5

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