Skin nerve regeneration and burn wound healing following spinal nerve root incision

Burn wounds were produced on two sides on the backs of Wistar rats, in addition to denervation on one side. The skin neural regeneration at the injury site and burn wound healing were evaluated following spinal nerve root incision. No nerve regeneration was observed in the burn wound region post-denervation, and the degree of epithelization was significantly less than the control group. With increasing time, expression of type I collagen, which plays a supporting role, and collagen Ill, which exhibits elastic properties, were significantly increased in the two groups, but the expression was less in the denervation group compared with the control group, and the wound healing was faster in the control group. The ratio of type I collagen to type Ill collagen was significantly lower in the denervation group compared with the control group. The ratio gradually decreased with prolonged time in the denervation group, but remained unchanged in the control group. However, the elasticity of the tissues in the denervation group was better than the control group. During bum wound healing, innervations can promote wound healing, but denervation can improve the quality of wound remodeling.