Evaluation of the α2A-adrenergic receptor gene in a heritable form of temporal lobe epilepsy

被引：8

作者：

Wilson, MH

Puranam, RS

Ottman, R

Gilliam, C

Limbird, LE

George, AL

McNamara, JO

机构：

[1] Vanderbilt Univ, Dept Pharmacol, Med Ctr, Nashville, TN 37232 USA

[2] Columbia Presbyterian Med Ctr, Gertrude H Sergievsky Ctr, New York, NY 10032 USA

[3] Columbia Presbyterian Med Ctr, Sch Publ Hlth, Div Epidemiol, New York, NY 10032 USA

[4] Duke Univ, Med Ctr, Dept Med, Div Neurol, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

[6] Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USA

[7] Duke Univ, Med Ctr, Dept Canc Biol, Durham, NC 27710 USA

[8] Vet Affairs Med Ctr, Durham, NC 27705 USA

[9] Columbia Presbyterian Med Ctr, Dept Genet & Dev, New York, NY 10032 USA

来源：

NEUROLOGY | 1998年 / 51卷 / 06期

关键词：

D O I：

10.1212/WNL.51.6.1730

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An autosomal dominant form of human temporal lobe epilepsy (TLE) has been mapped to a region of chromosome 10q that contains the intronless alpha(2A)-adrenergic receptor (alpha(2A)AR) gene. Because mutation of the alpha(2A)AR gene in the mouse fosters epileptogenesis, we developed methods for analysis of the alpha(2A)AR coding region applicable to any pathophysiologic state in which the alpha(2A)AR could be implicated in the disease mechanism. This study rules out mutations in the alpha(2A)AR coding region as causal for this form of autosomal dominant TLE.

引用

页码：1730 / 1731

页数：2

共 10 条

[1] ALPHA-NORADRENALINE MODULATION OF D,L-ALLYLGLYCINE SEIZURES [J].