The suprachoroidal pathways: a new drug delivery route to the back of the eye

被引：43

作者：

Rai, Uma Do J. P. ^{[1
]}

Young, Simon A. ^{[1
]}

Thrimawithana, Thilini R. ^{[1
]}

Abdelkader, Hamdy ^{[2
,3
]}

Alani, Adam W. G. ^{[4
]}

Pierscionek, Barbara ^{[2
]}

Alany, Raid G. ^{[2
,5
]}

机构：

[1] RMIT Univ, Sch Med Sci, Discipline Pharm, Bundoora, Vic 3083, Australia

[2] Kingston Univ London, Fac Sci Comp & Engn, Sch Pharm & Chem, Drug Discovery Delivery & Patient Care DDDPC Them, Kingston Upon Thames KT1 2EE, Surrey, England

[3] Menia Univ, Fac Pharm, Dept Pharmaceut, Al Minya, Egypt

[4] Oregon State Univ, Coll Pharm, Dept Pharmaceut Sci, Corvallis, OR 97331 USA

[5] Univ Auckland, Sch Pharm, Auckland 1, New Zealand

来源：

DRUG DISCOVERY TODAY | 2015年 / 20卷 / 04期

关键词：

POSTERIOR SEGMENT; SYSTEMIC ABSORPTION; HOLLOW MICRONEEDLES; SPACE; RABBIT; INJECTION; POLYMER; TIMOLOL; MODEL;

D O I：

10.1016/j.drudis.2014.10.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of safe and convenient drug delivery strategies for treatment of posterior segment eye diseases is challenging. Although intravitreal injection has wide acceptance amongst clinicians, its use is associated with serious side-effects. Recently, the suprachoroidal space (SCS) has attracted the attention of ophthalmologists and pharmaceutical formulators as a potential site for drug administration and delivery to the posterior segment of the eye. This review highlights the major constraints of drug delivery to the posterior eye segment, key anatomical and physiological features of the SCS and drug delivery applications of this route with emphasis on microneedles along with future perspectives.

引用

页码：491 / 495

页数：5

共 35 条

[1] Controlled and Continuous Release Ocular Drug Delivery Systems: Pros and Cons [J].

Abdelkader, Hamdy ;

Alany, Raid G. .

CURRENT DRUG DELIVERY, 2012, 9 (04) :421-430

[2]

ANDERSON JA, 1980, ARCH OPHTHALMOL-CHIC, V98, P350

[3] NASAL AND CONJUNCTIVAL CONTRIBUTIONS TO THE SYSTEMIC ABSORPTION OF TOPICAL TIMOLOL IN THE PIGMENTED RABBIT - IMPLICATIONS IN THE DESIGN OF STRATEGIES TO MAXIMIZE THE RATIO OF OCULAR TO SYSTEMIC ABSORPTION [J].

CHANG, SC ;

LEE, VHL .

JOURNAL OF OCULAR PHARMACOLOGY, 1987, 3 (02) :159-169

[4] Current and future ophthalmic drug delivery systems. A shift to the posterior segment [J].

del Amo, Eva M. ;

Urtti, Arto .

DRUG DISCOVERY TODAY, 2008, 13 (3-4) :135-143

[5] TOPICALLY APPLIED OXYMETAZOLINE - OCULAR VASOCONSTRICTIVE ACTIVITY, PHARMACOKINETICS, AND METABOLISM [J].

DUZMAN, E ;

ANDERSON, J ;

VITA, JB ;

LUE, JC ;

CHEN, CC ;

LEOPOLD, IH .

ARCHIVES OF OPHTHALMOLOGY, 1983, 101 (07) :1122-1126

[6]

Einmahl S, 2002, INVEST OPHTH VIS SCI, V43, P1533

[7]

German E, 1970, N Engl J Med, V282, P689

[8] Transscleral drug delivery for posterior segment disease [J].

Geroski, DH ;

Edelhauser, HF .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 52 (01) :37-48

[9] Treatment of Acute Posterior Uveitis in a Porcine Model by Injection of Triamcinolone Acetonide Into the Suprachoroidal Space Using Microneedles [J].

Gilger, Brian C. ;

Abarca, Eva M. ;

Salmon, Jacklyn H. ;

Patel, Samirkumar .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (04) :2483-2492

[10]

Guyer DR., 2006, RETINA-J RET VIT DIS, P33

← 1 2 3 4 →