Gold(I)-Catalyzed Tandem Synthesis of Polycyclic Dihydroquinazolinones

被引：3

作者：

Sun, Jingyang

Song, Yoona

Ryu, Jae-Sang ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea

来源：

CATALYSTS | 2021年 / 11卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

gold; silver; dihydroquinazolinone; tandem reaction; cascade reaction; CATALYZED CASCADE REACTIONS; RING-CLOSURE REACTIONS; EASY ACCESS; ALKYNES; HYDROAMINATION; HETEROCYCLES; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONE; HYDROARYLATION; CONSTRUCTION; STRATEGIES;

D O I：

10.3390/catal11121436

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones.

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页数：14

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