Approach to Pediatric Obesity and Nonalcoholic Fatty Liver Disease

被引：1

作者：

Bartlett, Johanna M. Ascher ^{[1
]}

Mittal, Naveen ^{[2
,3
]}

机构：

[1] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Pediat, San Antonio, TX 78229 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Pediat Gastroenterol & Hepatol, San Antonio, TX 78229 USA

来源：

PEDIATRIC ANNALS | 2021年 / 50卷 / 11期

关键词：

EXPERT COMMITTEE; DIAGNOSIS; CHILDREN; RECOMMENDATIONS; ADOLESCENTS; HEPATOLOGY;

D O I：

10.3928/19382359-20211019-02

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

With the rapidly increasing numbers of children diagnosed with obesity, pediatricians are facing more and more challenges regarding the complex care of these patients. Pediatric nonalcoholic fatty liver disease (NAFLD) is now the most prevalent cause of pediatric chronic liver disease, given its association with obesity. As NAFLD increases a child's risk of developing long-term complications including cirrhosis and hepatocellular carcinoma, efficient diagnosis and effective management is paramount. This article aims to provide a brief overview of NALFD, and discuss the updated diagnosis and management approach for pediatric NAFLD, with a particular focus on the role of the pediatrician.

引用

页码：E474 / E477

页数：4

共 20 条

[1]

Alkhouri N, 2012, HEPATOLOGY, V55, P331, DOI [10.1002/hep.24767, 10.1002/hep.24721]

[2] A Combination of the Pediatric NAFLD Fibrosis Index and Enhanced Liver Fibrosis Test Identifies Children With Fibrosis [J].

Alkhouri, Naim ;

Carter-Kent, Christine ;

Lopez, Rocio ;

Rosenberg, William M. ;

Pinzani, Massimo ;

Bedogni, Giorgio ;

Feldstein, Ariel E. ;

Nobili, Valerio .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2011, 9 (02) :150-155

[3] Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: Summary report [J].

Barlow, Sarah E. .

PEDIATRICS, 2007, 120 :S164-S192

[4] Pediatric non-alcoholic fatty liver disease: an increasing public health issue [J].

Berardis, S. ;

Sokal, E. .

EUROPEAN JOURNAL OF PEDIATRICS, 2014, 173 (02) :131-139

[5] New pediatric percentiles of liver enzyme serum levels (alanine aminotransferase, aspartate aminotransferase, -glutamyltransferase): Effects of age, sex, body mass index, and pubertal stage [J].

Bussler, Sarah ;

Vogel, Mandy ;

Pietzner, Diana ;

Harms, Kristian ;

Buzek, Theresa ;

Penke, Melanie ;

Haendel, Norman ;

Koerner, Antje ;

Baumann, Ulrich ;

Kiess, Wieland ;

Flemming, Gunter .

HEPATOLOGY, 2018, 68 (04) :1319-1330

[6] The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases [J].

Chalasani, Naga ;

Younossi, Zobair ;

Lavine, Joel E. ;

Charlton, Michael ;

Cusi, Kenneth ;

Rinella, Mary ;

Harrison, Stephen A. ;

Brunt, Elizabeth M. ;

Sanyal, Arun J. .

HEPATOLOGY, 2018, 67 (01) :328-357

[7] Nonalcoholic Fatty Liver Disease [J].

Fusillo, Steven ;

Rudolph, Bryan .

PEDIATRICS IN REVIEW, 2015, 36 (05) :198-206

[8] Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents The TONIC Randomized Controlled Trial [J].

Lavine, Joel E. ;

Schwimmer, Jeffrey B. ;

Van Natta, Mark L. ;

Molleston, Jean P. ;

Murray, Karen F. ;

Rosenthal, Philip ;

Abrams, Stephanie H. ;

Scheimann, Ann O. ;

Sanyal, Arun J. ;

Chalasani, Naga ;

Tonascia, James ;

Uenalp, Aynur ;

Clark, Jeanne M. ;

Brunt, Elizabeth M. ;

Kleiner, David E. ;

Hoofnagle, Jay H. ;

Robuck, Patricia R. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (16) :1659-1668

[9] Treatment of nonalcoholic fatty liver disease in children: TONIC trial design [J].

Lavine, Joel E. ;

Schwimmer, Jeffrey B. ;

Molleston, Jean P. ;

Scheimann, Ann O. ;

Murray, Karen F. ;

Abrams, Stephanie H. ;

Rosenthal, Philip ;

Sanyal, Arun J. ;

Robuck, Patricia R. ;

Brunt, Elizabeth M. ;

Unalp, Aynur ;

Tonascia, James .

CONTEMPORARY CLINICAL TRIALS, 2010, 31 (01) :62-70

[10] The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering [J].

Magge, Sheela N. ;

Goodman, Elizabeth ;

Armstrong, Sarah C. .

PEDIATRICS, 2017, 140 (02)

← 1 2 →