Application of atomic force microscopy in cancer research

被引：142
作者：
Deng, Xiangying [1 ,2 ,3 ,4 ,5 ,6 ]
Xiong, Fang [4 ,5 ]
Li, Xiayu [4 ,5 ,6 ]
Xiang, Bo [1 ,2 ,3 ,4 ,5 ,6 ]
Li, Zheng [1 ,2 ,3 ,4 ,5 ,6 ]
Wu, Xu [4 ,5 ,7 ]
Guo, Can [4 ,5 ]
Li, Xiaoling [1 ,2 ,3 ,4 ,5 ,6 ]
Li, Yong [4 ,5 ,8 ]
Li, Guiyuan [1 ,2 ,3 ,4 ,5 ,6 ]
Xiong, Wei [1 ,2 ,3 ,4 ,5 ,6 ]
Zeng, Zhaoyang [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Cent South Univ, Key Lab Carcinogenesis Chinese, Minist Hlth, Changsha 410013, Hunan, Peoples R China
[2] Cent South Univ, Hunan Key Lab Translat Radiat Oncol, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China
[3] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China
[4] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China
[5] Cent South Univ, Sch Basic Med Sci, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China
[6] Cent South Univ, Hunan Key Lab Nonresolving Inflammat & Canc, Dis Genome Res Ctr, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China
[7] Univ North Dakota, Dept Chem, Grand Forks, ND 58202 USA
[8] Cleveland Clin, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2018年 / 16卷
基金：
中国国家自然科学基金;
关键词：
Atomic force microscopy; Cancer cells; Morphology; Mechanical properties; BREAST-CANCER; COLON-CANCER; NASOPHARYNGEAL CARCINOMA; AFM INDENTATION; CELL MECHANICS; CIRCULAR RNAS; HOMEOBOX GENE; CURCUMIN; MICRORNAS; EXPRESSION;
D O I：
10.1186/s12951-018-0428-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and molecules. Recent advances have enabled its application in cancer research and diagnosis. The physicochemical properties of live cells undergo changes when their physiological conditions are altered. These physicochemical properties can therefore reflect complex physiological processes occurring in cells. When cells are in the process of carcinogenesis and stimulated by external stimuli, their morphology, elasticity, and adhesion properties may change. AFM can perform surface imaging and ultrastructural observation of live cells with atomic resolution under near-physiological conditions, collecting force spectroscopy information which allows for the study of the mechanical properties of cells. For this reason, AFM has potential to be used as a tool for high resolution research into the ultrastructure and mechanical properties of tumor cells. This review describes the working principle, working mode, and technical points of atomic force microscopy, and reviews the applications and prospects of atomic force microscopy in cancer research.
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页数：15
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