Process Intensification for the Synthesis of 6-Allyl-6-azabicyclo[3.1.0]hex-3-en-2-ol from 1-Allylpyridinium Salt Using a Continuous UV-Light Photoflow Approach

被引：6
作者：
Fortunato, Milene A. G. [1 ]
Ly, Chi-Phong [1 ,2 ]
Siopa, Filipa [1 ]
Afonso, Carlos A. M. [1 ]
机构：
[1] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal
[2] Sorbonne Univ, CNRS, Inst Parisien Chim Mol, Fac Sci & Ingn,IPCM, 4 Pl Jussieu, F-75005 Paris, France
来源：
METHODS AND PROTOCOLS | 2019年 / 2卷 / 03期
关键词：
flow reaction; photochemistry; bicyclic aziridine; PHOTOCHEMICAL-TRANSFORMATIONS; PYRIDINIUM;
D O I：
10.3390/mps2030067
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A new home-made UV photochemical reactor (95 cm of irradiation zone) consisting of a 12 parallel quartz tubes flow reactor, PQT6 (95 cm under irradiation and an internal diameter of 0.6 cm) was assembled to perform photochemical transformations in continuous-flow. PQT6 was evaluated for the photoreaction of 1-allylpyridinium bromide (1a) to 6-allyl-6-azabicyclo[3.1.0]hex-3-en-2-ol (2a), in a continuous process. This technology provides reduced reaction times, continuous production of 2a, and a productivity of 129 mg h(-1), corresponding to 1.94 g of isolated 2a after 15 h of irradiation.
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页数：9
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