Asymmetric transfer hydrogenation of ketones with bifunctional transition metal-based molecular

被引：1050

作者：

Ikariya, Takao ^{[1
]}

Blacker, A. John ^{[2
,3
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Sci, Dept Appl Chem, Tokyo 1528552, Japan

[2] NPIL Pharma, Huddersfield HD1 9GA, W Yorkshire, England

[3] Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2007年 / 40卷 / 12期

关键词：

D O I：

10.1021/ar700134q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent development of conceptually new chiral bifunctional transition metal based catalysts for asymmetric reductive transformations is described. The chiral bifunctional molecular catalyst promoted reduction is now realized to be a powerful tool to access chiral compounds in organic synthetic procedures in both academia and industry. Based on structural investigation of the actual catalyst and its intermediates and a deep understanding of the reaction mechanism, this asymmetric reduction system can be widely used to produce valuable chiral alcohols ani is now is applicable to commercial scale production.

引用

页码：1300 / 1308

页数：9

共 76 条

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