Synthesis, antimalarial and antibacterial activities of 3-amino acid- and aryl amine-substituted 2-methyl-3H-quinalzolin-4-ones

被引：12

作者：

Meyyanathan, Subramania Nainar ^{[1
]}

Ramu, Mamillapalli ^{[1
]}

Suresh, Bhojraj ^{[1
]}

机构：

[1] JSS Coll Pharm, Dept Pharmaceut Anal, Ooty 643001, Tamil Nadu, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2010年 / 19卷 / 08期

关键词：

Quinazolinone; Antimalarial; Plasmodium yoelii; Swiss mice model; Antibacterial; SPOROZOITE-INDUCED INFECTIONS; AZITHROMYCIN; BLOOD; MICE;

D O I：

10.1007/s00044-009-9245-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 2-methyl-3H-quinazolinones substituted at the third position with amino acids (2-5) and aryl amine (6, 7) was designed, synthesized, and analyzed by infrared, NMR, and mass spectral analysis. Further, the compounds were screened for their in vivo antimalarial activity using the rodent malaria parasite Plasmodium yoelii (N-67) with the Swiss mice model. The compounds were also tested for their antibacterial activity.

引用

页码：993 / 999

页数：7

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