Protective effects of berberine against amyloid beta-induced toxicity in cultured rat cortical neurons

被引：4

作者：

Wang, Jing ^{[1
]}

Zhang, Yanjun ^{[1
]}

Du, Shuai ^{[1
]}

Zhang, Mixia ^{[1
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab TCM Pharmacol, Tianjin Key Lab TCM Chem & Anal, Chinese Mat Med Coll, Tianjin 300193, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 03期

关键词：

activated caspase-3; amyloid beta; berberine; cortical neurons; ALZHEIMERS-DISEASE; PRECURSOR PROTEIN; INVOLVEMENT; NEUROTOXICITY; HIPPOCAMPUS; CASPASE-3; EXTRACT; PEPTIDE; ACCUMULATION; ACTIVATION;

D O I：

10.3969/j.issn.1673-5374.2011.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Berberine, a major constituent of Coptidis rhizoma, exhibits neural protective effects. The present study analyzed the potential protective effect of berberine against amyloid beta-induced cytotoxicity in rat cerebral cortical neurons. Alzheimer's disease cell models were treated with 0.5 and 2 mu mol/L berberine for 36 hours to inhibit amyloid beta-induced toxicity. Methyl thiazolyl tetrazolium assay and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining results showed that berberine significantly increased cell viability and reduced cell apoptosis in primary cultured rat cortical neurons. In addition, western blot analysis revealed a protective effect of berberine against amyloid beta-induced toxicity in cultured cortical neurons, which coincided with significantly decreased abnormal up-regulation of activated caspase-3. These results showed that berberine exhibited a protective effect against amyloid beta-induced cytotoxicity in cultured rat cortical neurons.

引用

页码：183 / 187

页数：5

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