Pregnancies in women with Turner syndrome: a retrospective multicentre UK study

被引：0

作者：

Cauldwell, M. ^{[1
]}

Steer, P. J. ^{[2
]}

Adamson, D. ^{[3
]}

Alexander, C. ^{[4
]}

Allen, L. ^{[5
]}

Bhagra, C. ^{[6
]}

Bolger, A. ^{[7
]}

Bonner, S. ^{[8
]}

Calanchini, M. ^{[9
]}

Carroll, A. ^{[10
]}

Casey, R. ^{[11
]}

Curtis, S. ^{[12
]}

Head, C. ^{[13
]}

English, K. ^{[14
]}

Hudsmith, L. ^{[15
]}

James, R. ^{[16
]}

Joy, E. ^{[14
]}

Keating, N. ^{[17
]}

MacKiliop, L. ^{[18
,19
]}

McAuliffe, F. ^{[17
]}

Morris, R. K. ^{[20
]}

Mohan, A. ^{[21
]}

Von Klemperer, K. ^{[22
]}

Kaler, M. ^{[23
]}

Rees, D. A. ^{[24
]}

Shetty, A. ^{[25
]}

Siddiqui, F. ^{[26
]}

Simpson, L. ^{[4
]}

Stocker, L. ^{[27
]}

Timmons, P. ^{[28
]}

Vause, S. ^{[8
]}

Turner, H. E. ^{[29
]}

机构：

[1] St George Hosp, Maternal Med Serv, Dept Obstet, Blackshaw Rd, London SW17 0QT, England

[2] Chelsea & Westminster Hosp, Acad Dept Obstet & Gynaecol, London, England

[3] Univ Hosp Coventry & Warwickshire, Dept Cardiol, Coventry, W Midlands, England

[4] Edinburgh Royal Infirm, Dept Obstet, Edinburgh, Midlothian, Scotland

[5] Cardiff & Vale Univ Hlth Board, Dept Endocrinol, Cardiff, Wales

[6] Addenbrookes Hosp, Dept Cardiol, Cambridge, England

[7] Glenfield Hosp, Dept Adult Congenital Heart Dis, Leicester, Leics, England

[8] Manchester Univ Fdn Trust, St Marys Managed Clin Serv, Manchester, Lancs, England

[9] Oxford Univ Hosp NHS Fdn Trust, Oxford Ctr Diabet Endocrinol & Metab, Dept Endocrinol, Oxford, England

[10] Univ Hosp Southampton NHS Fdn Trust, Dept Congenital Cardiol, Southampton, Hants, England

[11] Addenbrookes Hosp, Dept Endocrinol, Cambridge, England

[12] Univ Hosp Bristol NHS Fdn Trust, Adult Congenital Heart Dis Serv, Bristol, Avon, England

[13] Norfolk & Norwich Univ Hosp, Cardiol Dept, Norwich, Norfolk, England

[14] Leeds Teaching Hosp NHS Trust, Dept Adult Congenital Heart Dis, Leeds, W Yorkshire, England

[15] Univ Hosp Birmingham, Dept Adult Congenital Heart Dis, Birmingham, W Midlands, England

[16] Univ Hosp Sussex, Dept Cardiol, Brighton, E Sussex, England

[17] Univ Coll Dublin, Natl Matern Hosp, Sch Med, UCD Perinatal Res Ctr,Dept Obstet, Dublin, Ireland

[18] Oxford Univ Hosp NHS Fdn Trust, Womens Ctr, Oxford, England

[19] Oxford Univ Hosp NHS Fdn Trust, NIHR Oxford Biomed Res Ctr, Oxford, England

[20] Birmingham Womens & Childrens NHS Fdn, Univ Birmingham, Acad Dept Obstet, Birmingham, W Midlands, England

[21] Univ Hosp Bristol NHS Fdn Trust, Dept Obstet, Bristol, Avon, England

[22] Barts Heart Ctr, Adult Congenital Heart Dis, London, England

[23] Royal London Hosp, Dept Obstet, London, England

[24] Cardiff Univ, Neurosci & Mental Hlth Res Inst, Cardiff, Wales

[25] Aberdeen Royal Infirm, Dept Obstet, Aberdeen, Scotland

[26] Royal Leicester Infirm, Dept Obstet, Leicester, Leics, England

[27] Princess Anne Hosp, Dept Obstet, Southampton, Hants, England

[28] Norfolk & Norwich Univ Hosp, Dept Obstet, Norwich, Norfolk, England

[29] Oxford Univ Hosp NHS Fdn Trust, Dept Endocrinol, Oxford, England

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2022年 / 129卷 / 05期

关键词：

Aortic dissection; pregnancy; Turner syndrome; OOCYTE DONATION; AORTIC DISSECTION; FERTILITY; OUTCOMES;

D O I：

10.1530/endoabs.77.p106; 10.1111/1471-0528.17025

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective To determine the characteristics and outcomes of pregnancy in women with Turner syndrome. Design Retrospective 20-year cohort study (2000-20). Setting Sixteen tertiary referral maternity units in the UK. Population or sample A total of 81 women with Turner syndrome who became pregnant. Methods Retrospective chart analysis. Main outcome measures Mode of conception, pregnancy outcomes. Results We obtained data on 127 pregnancies in 81 women with a Turner phenotype. All non-spontaneous pregnancies (54/127; 42.5%) were by egg donation. Only 9/31 (29%) pregnancies in women with karyotype 45,X were spontaneous, compared with 53/66 (80.3%) pregnancies in women with mosaic karyotype 45,X/46,XX (P < 0.0001). Women with mosaic karyotype 45,X/46,XX were younger at first pregnancy by 5.5-8.5 years compared with other Turner syndrome karyotype groups (P < 0.001), and more likely to have a spontaneous menarche (75.8% versus 50% or less, P = 0.008). There were 17 miscarriages, three terminations of pregnancy, two stillbirths and 105 live births. Two women had aortic dissection (2.5%); both were 45,X karyotype with bicuspid aortic valves and ovum donation pregnancies, one died. Another woman had an aortic root replacement within 6 months of delivery. Ten of 106 (9.4%) births with gestational age data were preterm and 22/96 (22.9%) singleton infants with birthweight/gestational age data weighed less than the tenth centile. The caesarean section rate was 72/107 (67.3%). In only 73/127 (57.4%) pregnancies was there documentation of cardiovascular imaging within the 24 months before conceiving. Conclusions Pregnancy in women with Turner syndrome is associated with major maternal cardiovascular risks; these women deserve thorough cardiovascular assessment and counselling before assisted or spontaneous pregnancy managed by a specialist team. Tweetable abstract Pregnancy in women with Turner syndrome is associated with an increased risk of aortic dissection.

引用

页码：796 / 803

页数：8

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