Macular Telangiectasia type 2: multimodal assessment of retinal function and microstructure

被引:2
作者
Ledolter, Anna A. [1 ]
Ristl, Robin [2 ]
Palmowski-Wolfe, Anja M. [3 ]
Montuoro, Alessio [1 ]
Deak, Gabor G. [1 ]
Sacu, Stefan [1 ]
Holder, Graham E. [4 ,5 ]
Schmidt-Erfurth, Ursula [1 ]
Ritter, Markus [1 ]
机构
[1] Med Univ Vienna, Dept Ophthalmol, Waehringer Guertel 18-20, A-1090 Vienna, Austria
[2] Med Univ Vienna, Sect Med Stat, Ctr Med Stat Informat & Intelligent Syst, Vienna, Austria
[3] Univ Basel, Dept Ophthalmol, Basel, Switzerland
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore
[5] UCL Inst Ophthalmol, London, England
关键词
macular telangiectasia type 2; microperimetry; Muller cells; multifocal electroretinogram; retina; OPTICAL COHERENCE TOMOGRAPHY; MULTIFOCAL ELECTRORETINOGRAPHY; FUNDUS AUTOFLUORESCENCE; MACTEL; PROGRESSION;
D O I
10.1111/aos.15072
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose To assess the impact of neurodegenerative morphologic alterations due to macular telangiectasia type 2 (MacTel) on microperimetry (MP) and multifocal electroretinography (mfERG). Methods Thirty-five eyes of 18 patients with MacTel were examined using spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), mfERG and MP. Software was used to match SD-OCT B-scans with the corresponding retinal sensitivity map and multifocal electroretinograms (mfERGs), thus enabling direct structure/function correlation. Results Loss of the ellipsoid zone (EZ) had the strongest negative association with retinal sensitivity (16.77 dB versus 4.58 dB, adj. p < 0.001) of all parameters examined, and a limited negative effect on mfERGs (0.32 SD versus -1.97 SD adj. p = 0.121). Ellipsoid zone (EZ) irregularity was associated with reduced MP values but preserved mfERGs. There was a significant association between areas of inner retinal hyporeflectivity and loss of MP sensitivity (adj. p < 0.001) but the reduction in sensitivity was less than in locations with EZ loss. Areas of mfERG abnormality showed similar sensitivity loss with either inner retinal hyporeflectivity or EZ loss (adj. p = 0.063). In areas with EZ loss alone, preservation of the external limiting membrane (ELM) was associated with higher MP values than in areas with additional ELM loss; the integrity of the ELM alone was not associated with changes either in MP or mfERG. Increased FAF was observed in 51% of eyes, mixed/reduced FAF in 40%, and no abnormality was detected in 9% of eyes. Conclusion The data suggest both MP and mfERG to be useful non-invasive modalities for detecting localised macular dysfunction in MacTel. The findings suggest a different sensitivity of the two modalities to inner and outer retinal changes in macular function and are therefore complementary.
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收藏
页码:E1240 / E1252
页数:13
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