iPS Cells in Type 1 Diabetes Research and Treatment

被引：14

作者：

Maehr, R. ^{[1
]}

机构：

[1] Harvard Univ, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 89卷 / 05期

关键词：

PLURIPOTENT STEM-CELLS; EFFICIENT DIFFERENTIATION; GENERATION; ORIGIN;

D O I：

10.1038/clpt.2011.1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Induced pluripotent stem (iPS) cells, with their ability to differentiate into every cell type of the body, represent a perfect source for cell-replacement therapies in type 1 diabetes (T1D). Hence, there is a need to optimize the differentiation protocols to generate fully glucose-responsive and mature cells. In addition, the use of iPS cells could make possible the generation of patient-specific disease models that could further our understanding of the root cause of autoimmune diabetes.

引用

页码：750 / 753

页数：4

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