Sleep-Related Hypermotor Epilepsy: Etiology, Electro-Clinical Features, and Therapeutic Strategies

被引:12
作者
Wan, Huijuan [1 ,2 ,3 ]
Wang, Xing [4 ]
Chen, Yiyi [1 ,2 ]
Jiang, Bin [3 ]
Chen, Yangmei [5 ]
Hu, Wenhan [6 ]
Zhang, Kai [7 ]
Shao, Xiaoqiu [1 ,2 ]
机构
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 119 South 4th Ring West Rd, Beijing 100070, Peoples R China
[2] China Natl Clin Res Ctr Neurol Dis NCRC ND, Beijing, Peoples R China
[3] Xiamen Univ, Affiliated Hosp 1, Dept Neurol, Xiamen, Peoples R China
[4] Chongqing Univ, Dept Neurol, Chongqing Emergency Med Ctr, Cent Hosp, Chongqing, Peoples R China
[5] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China
[6] Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China
[7] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
关键词
semiology; seizure onset zone; SOZ; epileptogenic zone; hypermotor; electroencephalogram; FRONTAL-LOBE EPILEPSY; CYCLIC ALTERNATING PATTERN; NICOTINIC ACETYLCHOLINE-RECEPTORS; MINOR MOTOR EVENTS; HYPERKINETIC SEIZURES; PAROXYSMAL AROUSALS; INTRACEREBRAL RECORDINGS; CORTICAL DEVELOPMENT; EMOTION-REGULATION; SURGICAL-TREATMENT;
D O I
10.2147/NSS.S330986
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Sleep-related hypermotor epilepsy (SHE) is a group of clinical syndromes with heterogeneous etiologies. SHE is difficult to diagnose and treat in the early stages due to its diverse clinical manifestations and difficulties in differentiating from non-epileptic events, which seriously affect patients' quality of life and social behavior. The overall prognosis for SHE is unsatisfactory, but different etiologies affect patients' prognoses. Surgical treatment is an effective method for carefully selected patients with refractory SHE; nevertheless, preoperative assessment remains challenging because of the low sensitivity of noninvasive scalp electroencephalogram and imaging to detect abnormalities. However, through a careful analysis of semiology, the clinician can deduce the potential epileptogenic zone. This paper summarizes the research status of the background, etiology, electro-clinical features, diagnostic criteria, prognosis, and treatment of SHE to provide a more in-depth understanding of its pathophysiological mechanism, improve the accuracy in the diagnosis of this group of syndromes, and further explore more targeted therapy plans.
引用
收藏
页码:2065 / 2084
页数:20
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