Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

被引:6
|
作者
Dantas, Claudio R. [1 ]
de Freitas, Jucleiton J. R. [2 ]
Barbosa, Queila P. S. [2 ]
Militao, Gardenia C. G. [3 ]
Silva, Thiago D. S. [3 ]
da Silva, Teresinha G. [4 ]
Paulino, Antonio A. S. [5 ]
Freitas, Juliano C. R. [1 ,6 ]
Oliveira, Roberta A. [2 ]
Menezes, Paulo H. [2 ]
机构
[1] Univ Fed Rural Pernambuco, Dept Quim, Recife, PE, Brazil
[2] Univ Fed Pernambuco, Dept Quim Fundamental, Recife, PE, Brazil
[3] Univ Fed Pernambuco, Dept Fisiol & Farmacol, Recife, PE, Brazil
[4] Univ Fed Pernambuco, Dept Antibiot, Recife, PE, Brazil
[5] Univ Sao Paulo, Inst Quim, Sao Paulo, SP, Brazil
[6] UFCG, Ctr Educ & Saude, Cuite, PB, Brazil
关键词
CROSS-COUPLING REACTIONS; TERMINAL ALKYNES; IODINE MONOCHLORIDE; VINYLIC TELLURIDES; ARYL; HYDROTELLURATION; DIMERIZATION; ANALOGS; HALIDES;
D O I
10.1039/c6ob00945j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient approach for the synthesis of Z-1,3-enynes based on the coupling reaction of Z-vinyl tellurides and alkynes containing a pseudoglycoside moiety is described. The products were obtained in good yields via a stereoselective way. Preliminary screening against three tumor cell lines indicated that the synthesized compounds are promising intermediates for the synthesis of an array of more potent target structures.
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页码:6786 / 6794
页数:9
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