Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

被引：6

作者：

Dantas, Claudio R. ^{[1
]}

de Freitas, Jucleiton J. R. ^{[2
]}

Barbosa, Queila P. S. ^{[2
]}

Militao, Gardenia C. G. ^{[3
]}

Silva, Thiago D. S. ^{[3
]}

da Silva, Teresinha G. ^{[4
]}

Paulino, Antonio A. S. ^{[5
]}

Freitas, Juliano C. R. ^{[1
,6
]}

Oliveira, Roberta A. ^{[2
]}

Menezes, Paulo H. ^{[2
]}

机构：

[1] Univ Fed Rural Pernambuco, Dept Quim, Recife, PE, Brazil

[2] Univ Fed Pernambuco, Dept Quim Fundamental, Recife, PE, Brazil

[3] Univ Fed Pernambuco, Dept Fisiol & Farmacol, Recife, PE, Brazil

[4] Univ Fed Pernambuco, Dept Antibiot, Recife, PE, Brazil

[5] Univ Sao Paulo, Inst Quim, Sao Paulo, SP, Brazil

[6] UFCG, Ctr Educ & Saude, Cuite, PB, Brazil

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 28期

关键词：

CROSS-COUPLING REACTIONS; TERMINAL ALKYNES; IODINE MONOCHLORIDE; VINYLIC TELLURIDES; ARYL; HYDROTELLURATION; DIMERIZATION; ANALOGS; HALIDES;

D O I：

10.1039/c6ob00945j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient approach for the synthesis of Z-1,3-enynes based on the coupling reaction of Z-vinyl tellurides and alkynes containing a pseudoglycoside moiety is described. The products were obtained in good yields via a stereoselective way. Preliminary screening against three tumor cell lines indicated that the synthesized compounds are promising intermediates for the synthesis of an array of more potent target structures.

引用

页码：6786 / 6794

页数：9

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