Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

被引:6
|
作者
Dantas, Claudio R. [1 ]
de Freitas, Jucleiton J. R. [2 ]
Barbosa, Queila P. S. [2 ]
Militao, Gardenia C. G. [3 ]
Silva, Thiago D. S. [3 ]
da Silva, Teresinha G. [4 ]
Paulino, Antonio A. S. [5 ]
Freitas, Juliano C. R. [1 ,6 ]
Oliveira, Roberta A. [2 ]
Menezes, Paulo H. [2 ]
机构
[1] Univ Fed Rural Pernambuco, Dept Quim, Recife, PE, Brazil
[2] Univ Fed Pernambuco, Dept Quim Fundamental, Recife, PE, Brazil
[3] Univ Fed Pernambuco, Dept Fisiol & Farmacol, Recife, PE, Brazil
[4] Univ Fed Pernambuco, Dept Antibiot, Recife, PE, Brazil
[5] Univ Sao Paulo, Inst Quim, Sao Paulo, SP, Brazil
[6] UFCG, Ctr Educ & Saude, Cuite, PB, Brazil
关键词
CROSS-COUPLING REACTIONS; TERMINAL ALKYNES; IODINE MONOCHLORIDE; VINYLIC TELLURIDES; ARYL; HYDROTELLURATION; DIMERIZATION; ANALOGS; HALIDES;
D O I
10.1039/c6ob00945j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient approach for the synthesis of Z-1,3-enynes based on the coupling reaction of Z-vinyl tellurides and alkynes containing a pseudoglycoside moiety is described. The products were obtained in good yields via a stereoselective way. Preliminary screening against three tumor cell lines indicated that the synthesized compounds are promising intermediates for the synthesis of an array of more potent target structures.
引用
收藏
页码:6786 / 6794
页数:9
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