Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents

被引：41

作者：

Kuo, Ping-Chung ^{[3
]}

Shen, Yuh-Chiang ^{[4
]}

Yang, Mei-Lin ^{[1
]}

Wang, Su-Hui ^{[3
]}

Thang, Tran Dinh ^{[5
]}

Dung, Nguyen Xuan ^{[6
]}

Chiang, Po-Cheng ^{[7
]}

Lee, Kuo-Hsiung ^{[7
]}

Lee, E-Jian ^{[8
,9
,10
,11
]}

Wu, Tian-Shung ^{[1
,2
]}

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[2] Providence Univ, Dept Appl Chem, Taichung 433, Taiwan

[3] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan

[4] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[5] Vinh Univ, Dept Chem, Vinh City, Vietnam

[6] Hanoi Natl Univ, Coll Nat Sci, Dept Chem, Hanoi 10000, Vietnam

[7] Univ N Carolina, Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA

[8] Natl Cheng Kung Univ, Dept Surg, Neurosurg Serv, Neurophysiol Lab,Med Ctr, Tainan 70101, Taiwan

[9] Natl Cheng Kung Univ, Dept Anesthesiol, Neurosurg Serv, Neurophysiol Lab,Med Ctr, Tainan 70101, Taiwan

[10] Natl Cheng Kung Univ, Inst Biomed Engn, Med Ctr, Tainan 70101, Taiwan

[11] Natl Cheng Kung Univ, Sch Med, Tainan 70101, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 12期

关键词：

D O I：

10.1021/np070383f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cytotoxicity-guided phytochemical investigation of a methanolic extract of Croton tonkinensis afforded two new kaurane diterpenoids (1, 2) and 10 known ent-kaurane-type diterpenoids (3-12). The structures of I and 2 were based on analysis of spectroscopic and mass spectral data. Compounds 3-12 were identified by comparison of their spectroscopic and physical data with those reported in the literature. Selected compounds from this plant were examined for cytotoxic and anti-inflammatory activities. Compounds 4 and 9 showed the highest cytotoxic activity against the tested tumor cell lines. Compounds 3, 4, 6, 8, 9, and 11 had IC50 values less than 5 mu M and were more potent than the nonspecific NOS inhibitor L-NAME in inhibiting LPS-induced NO production.

引用

页码：1906 / 1909

页数：4

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