Functional oncocytic adrenocortical carcinoma

被引：20

作者：

Ali, Abdullah Essa ^{[1
]}

Raphael, Simon J. ^{[1
,2
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Dept Pathol, Toronto, ON M4N 3M5, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

ENDOCRINE PATHOLOGY | 2007年 / 18卷 / 03期

关键词：

functional; adrenal; carcinoma; oncocytic; aldosterone;

D O I：

10.1007/s12022-007-9000-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically the tumor showed several features of malignancy and electron microscopy confirmed oncocytic differentiation. This case is reported as the first case of an aldosterone and cortisol-producing malignancy with an oncocytic phenotype.

引用

页码：187 / 189

页数：3

共 14 条

[1]

Alexander A, 1998, J Assoc Physicians India, V46, P235

[2] Adrenocortical oncocytic tumors: Report of 10 cases and review of the literature [J].

Bisceglia, M ;

Ludovico, O ;

Di Mattia, A ;

Ben-Dor, D ;

Sandbank, J ;

Pasquinelli, G ;

Lau, SK ;

Weiss, LM .

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2004, 12 (03) :231-243

[3]

DeLellis RA, 2004, PATHOLOGY GENETICS T

[4] ONCOCYTIC ADRENAL-CORTICAL CARCINOMA [J].

ELNAGGAR, AK ;

EVANS, DB ;

MACKAY, B .

ULTRASTRUCTURAL PATHOLOGY, 1991, 15 (4-5) :549-556

[5] Oncocytic adrenocortical carcinoma: A morphologic, immunohistochemical and ultrastructural study of four cases [J].

Hoang, MP ;

Ayala, AG ;

Albores-Saavedra, J .

MODERN PATHOLOGY, 2002, 15 (09) :973-978

[6]

Krishnamurthy S, 2000, DIAGN CYTOPATHOL, V22, P299, DOI 10.1002/(SICI)1097-0339(200005)22:5<299::AID-DC8>3.0.CO

[7]

2-5

[8] Local recurrence of an oncocytic adrenocortical carcinoma with ovary metastasis [J].

Kurek, R ;

Von Knobloch, R ;

Feek, U ;

Heidenreich, A ;

Hofmann, R .

JOURNAL OF UROLOGY, 2001, 166 (03) :985-985

[9]

MCNICOL AM, 2000, CURRENT DIAGNOSTIC P, V6, P171

[10] Oncocytic adrenocortical carcinomas: A pathological and immunohistochemical study of four cases in comparison with conventional adrenocortical carcinomas [J].

Song, SY ;

Park, S ;

Kim, SR ;

Suh, YL .

PATHOLOGY INTERNATIONAL, 2004, 54 (08) :603-610

← 1 2 →