Detecting molecular fingerprints in single molecule force spectroscopy using pattern recognition

被引：11

作者：

Dietz, Hendrik ^{[1
]}

Rief, Matthias ^{[1
]}

机构：

[1] Tech Univ Munich, Phys Dept E22, D-85748 Garching, Germany

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS | 2007年 / 46卷 / 8B期

关键词：

single molecule; protein mechanics; force spectroscopy; AFM; pattern recognition; GFP;

D O I：

10.1143/JJAP.46.5540

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Single molecule force spectroscopy has given experimental access to the mechanical properties of protein molecules. Typically, less than 1% of the experimental recordings reflect true single molecule events due to abundant surface and multiple-molecule interactions. A key issue in single molecule force spectroscopy is thus to identify the characteristic mechanical '' fingerprint '' of a specific protein in noisy data sets. Here, we present an objective pattern recognition algorithm that is able to identify fingerprints in such noisy data sets.

引用

页码：5540 / 5542

页数：3

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