The effects of levodopa and ongoing deep brain stimulation on subthalamic beta oscillations in Parkinson's disease

被引：159

作者：

Giannicola, Gaia

Marceglia, Sara

Rossi, Lorenzo

Mrakic-Sposta, Simona

Rampini, Paolo ^{[2
]}

Tamma, Filippo ^{[3
]}

Cogiamanian, Filippo ^{[4
]}

Barbieri, Sergio ^{[4
]}

Priori, Alberto ^{[1
,5
]}

机构：

[1] Osped Maggiore Policlin, Dipartimento Sci Neurol, Ctr Clin Neurostimolaz Neurotecnol & Disordini Mo, Fdn IRCCS Ca Granda, I-20122 Milan, Italy

[2] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Unita Operat Neurochirurg, I-20122 Milan, Italy

[3] Osped F Miulli, Unita Operat Neurol, Bari, Italy

[4] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Unita Operat Neuorofisiopatol Clin, I-20122 Milan, Italy

[5] Univ Milan, Dipartimento Sci Neurol, Milan, Italy

来源：

EXPERIMENTAL NEUROLOGY | 2010年 / 226卷 / 01期

关键词：

Local field potentials; Deep brain stimulation; Subthalamic oscillations; Levodopa; Beta rhythm; Parkinson's disease; HIGH-FREQUENCY STIMULATION; NUCLEUS STIMULATION; AREA; DBS; MODULATION; DOPAMINE; MOVEMENT; RHYTHM; ATTENUATION; DYSKINESIAS;

D O I：

10.1016/j.expneurol.2010.08.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Local field potentials (LFPs) recorded through electrodes implanted in the subthalamic nucleus (STN) for deep brain stimulation (DBS) in patients with Parkinson's disease (PD) show that oscillations in the beta frequency range (8-20 Hz) decrease after levodopa intake. Whether and how DBS influences the beta oscillations and whether levodopa- and DBS-induced changes interact remains unclear. We examined the combined effect of levodopa and DBS on subthalamic beta LFP oscillations, recorded in nine patients with PD under four experimental conditions: without levodopa with DBS turned off; without levodopa with DBS turned on; with levodopa with DBS turned on; and with levodopa with DBS turned off. The analysis of STN-LFP oscillations showed that whereas levodopa abolished beta STN oscillations in all the patients (p = 0.026), DBS significantly decreased the beta oscillation only in five of the nine patients studied (p = 0.043). Another difference was that whereas levodopa completely suppressed beta oscillations, DBS merely decreased them. When we combined levodopa and DBS, the levodopa-induced beta disruption prevailed and combining levodopa and DBS induced no significant additive effect (p = 0.500). Our observations suggest that levodopa and DBS both modulate LFP beta oscillations. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：120 / 127

页数：8

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