The expanding universe of regulatory T cell subsets in cancer

被引：23
作者：
Gajewski, Thomas F. [1 ]
机构：
[1] Univ Chicago, Chicago, IL 60637 USA
来源：
IMMUNITY | 2007年 / 27卷 / 02期
关键词：
D O I：
10.1016/j.immuni.2007.08.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Evidence has indicated that failed antitumor immunity is dominated by immunosuppressive mechanisms within the tumor microenvironment. In this issue of Immunity, Peng et al. (2007) add to this list by describing tumor-infiltrating gamma delta T cells that have regulatory function.
引用
收藏
页码：185 / 187
页数：3
相关论文
共 10 条
  • [1] Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    Dannull, J
    Su, Z
    Rizzieri, D
    Yang, BK
    Coleman, D
    Yancey, D
    Zhang, AJ
    Dahm, P
    Chao, N
    Gilboa, E
    Vieweg, J
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (12) : 3623 - 3633
  • [2] Regulation of cutaneous malignancy by γδ T cells
    Girardi, M
    Oppenheim, DE
    Steele, CR
    Lewis, JM
    Glusac, E
    Filler, R
    Hobby, P
    Sutton, B
    Tigelaar, RE
    Hayday, AC
    [J]. SCIENCE, 2001, 294 (5542) : 605 - 609
  • [3] Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
    Groh, V
    Rhinehart, R
    Secrist, H
    Bauer, S
    Grabstein, KH
    Spies, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) : 6879 - 6884
  • [4] Inhibition of tumor rejection by γδ T cells and IL-10
    Ke, Y
    Kapp, LM
    Kapp, JA
    [J]. CELLULAR IMMUNOLOGY, 2003, 221 (02) : 107 - 114
  • [5] Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Mempel, Thorsten R.
    Pittet, Mikael J.
    Khazaie, Khashayarsha
    Weninger, Wolfgang
    Weissleder, Ralph
    von Boehmer, Harald
    von Andrian, Ulrich H.
    [J]. IMMUNITY, 2006, 25 (01) : 129 - 141
  • [6] Tumor-infiltrating γδ T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway
    Peng, Guangyong
    Wang, Helen Y.
    Peng, Weiyi
    Kiniwa, Yukiko
    Seo, Kook Heon
    Wang, Rong-Fu
    [J]. IMMUNITY, 2007, 27 (02) : 334 - 348
  • [7] Toll-like, receptor 8-mediated reversal of CD4+ regulatory T cell function
    Peng, GY
    Guo, Z
    Kiniwa, Y
    Voo, KS
    Peng, WY
    Fu, TH
    Wang, DY
    Li, YC
    Wang, HY
    Wang, RF
    [J]. SCIENCE, 2005, 309 (5739) : 1380 - 1384
  • [8] B cells inhibit induction of T cell-dependent tumor immunity
    Qin, ZH
    Richter, G
    Schüler, T
    Ibe, S
    Cao, XT
    Blankenstein, T
    [J]. NATURE MEDICINE, 1998, 4 (05) : 627 - 630
  • [9] From vanilla to 28 flavors: Multiple varieties of T regulatory cells
    Shevach, Ethan M.
    [J]. IMMUNITY, 2006, 25 (02) : 195 - 201
  • [10] Activated γδ T cells express the natural cytotoxicity receptor natural killer p44 and show cytotoxic activity against myeloma cells
    von Lilienfeld-Toal, M.
    Nattermann, J.
    Feldmann, G.
    Sievers, E.
    Frank, S.
    Strehl, J.
    Schmidt-Wolf, I. G. H.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2006, 144 (03) : 528 - 533
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