Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population

被引:3
作者
Liang, Li-li [1 ,2 ,3 ]
Chen, Lin [1 ,2 ,3 ]
Zhou, Meng-yuan [1 ,2 ,3 ]
Cai, Meng-yun [1 ,2 ,3 ]
Cheng, Jie [1 ,2 ]
Chen, Yi [1 ,2 ,3 ]
You, Si-kun [1 ,2 ,3 ]
Chen, Lin-bin [1 ,2 ,3 ]
Tang, Zi-bin [1 ,2 ,3 ]
Yang, Xi-li [4 ]
Chen, Can [5 ]
Liu, Xinguang [1 ,2 ,3 ]
Xiong, Xing-dong [1 ,2 ,3 ]
机构
[1] Guangdong Med Univ, Inst Aging Res, Dongguan 523808, Peoples R China
[2] Guangdong Med Univ, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan 523808, Peoples R China
[3] Guangdong Med Univ, Inst Biochem & Mol Biol, Zhanjiang 524023, Peoples R China
[4] First Peoples Hosp Foshan, Dept Cardiovasc Dis, Foshan 528000, Peoples R China
[5] Guangdong Med Univ, Dept Cardiovasc Dis, Affiliated Hosp, Zhanjiang 524023, Peoples R China
基金
中国国家自然科学基金;
关键词
GENOME-WIDE ASSOCIATION; HEART-DISEASE; ALCOHOL-CONSUMPTION; BLOOD-PRESSURE; RISK; POLYMORPHISM; LOCI; RATS; OVEREXPRESSION; HYPERTENSION;
D O I
10.1042/BSR20171320
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Endothelin-1 (ET-1) plays important roles in endothelial dysfunction, vascular physiology, inflammation, and atherosclerosis. Nonetheless, the role of ET-1 (EDN1) gene variants on coronary artery disease (CAD) risk remains poorly understood. The aim of the present study was to evaluate the role of EDN1 gene polymorphisms on individual susceptibility to CAD. We genotyped five tagSNPs (single-nucleotide polymorphisms) (rs6458155, rs4145451, rs9369217, rs3087459, and rs2070699) within EDN1 gene in 525 CAD patients and 675 control subjects. In a multivariate logistic regression analysis, we detected an association of rs6458155 in EDN1 gene with the CAD risk; compared with the TT homozygotes, the CT heterozygotes (odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.02-2.29, P=0.040) and the CC homozygotes (OR = 1.55, 95% CI = 1.01-2.36, P=0.043) were statistically significantly associated with the increased risk for CAD. A similar trend of the association was found in dominant model (OR = 1.53, 95% CI = 1.05-2.25, P=0.029). Consistently, the haplotype rs6458155C-rs4145451C containing rs6458155 C allele exhibited the increased CAD risk (OR = 1.22, 95% CI = 1.03-1.43, and P=0.018). In addition, CT genotype of rs6458155 conferred the increased plasma ET-1 levels compared with TT genotype (P<0.05). No association of the other four tagSNPs in EDN1 gene with CAD risk was observed. In conclusion, our study provides the first evidence that EDN1 tagSNP rs6458155 is associated with CAD risk in the Chinese Han population, which is probably due to the influence of the circulating ET-1 levels.
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页数:10
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