Regioselective synthesis of functionalized [1,8]-naphthyridine derivatives via three-component domino reaction under catalyst-free conditions

被引：19
作者：
Feng, Xian [1 ]
Wang, Jian-Jun [1 ]
Zhang, Juan-Juan [1 ]
Cao, Cheng-Pao [1 ]
Huang, Zhi-Bin [1 ]
Shi, Da-Qing [1 ]
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
来源：
GREEN CHEMISTRY | 2015年 / 17卷 / 02期
关键词：
ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; SOLVENT-FREE; SPIROOXINDOLE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS; ANTIINFLAMMATORY ACTIVITY; N; S-KETENE ACETAL; 4-COMPONENT; ANTICANCER;
D O I：
10.1039/c4gc01469c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A concise and efficient one-pot synthesis of functionalized [1,8] naphthyridine derivatives via a three-component domino reaction of glutaraldehyde, malononitrile, and beta-ketoamides, under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. The main advantages of this protocol are short reaction times, practical simplicity, high yields, catalyst-free conditions, cheap and benign solvents, and high regio- and stereo-selectivities.
引用
收藏
页码：973 / 981
页数：9
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