Maternal Serum Analytes as Predictors of Fetal Growth Restriction with Different Degrees of Placental Vascular Dysfunction

被引：9

作者：

Blitz, Matthew J. ^{[1
]}

Rochelson, Burton ^{[1
]}

Vohra, Nidhi ^{[1
]}

机构：

[1] N Shore Univ Hosp, Hofstra North Shore LIJ Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, 300 Community Dr, Manhasset, NY 11030 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2016年 / 36卷 / 02期

关键词：

Serum analytes; Doppler velocimetry; Placental vascular dysfunction; Placental pathology; Fetal growth restriction; Absent or reverse end-diastolic velocity; UTERINE ARTERY DOPPLER; HUMAN CHORIONIC-GONADOTROPIN; GESTATIONAL-AGE FETUSES; ADVERSE PREGNANCY OUTCOMES; ALPHA-FETOPROTEIN LEVELS; LOW UNCONJUGATED ESTRIOL; PLASMA-PROTEIN-A; FREE BETA-HCG; UMBILICAL ARTERY; 1ST TRIMESTER;

D O I：

10.1016/j.cll.2016.01.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Abnormal levels of maternal serum analytes have been associated with fetal growth restriction (FGR) and preeclampsia secondary to placental vascular dysfunction. Accurately identifying the FGR fetuses at highest risk for adverse outcomes remains challenging. Placental function can be assessed by Doppler analysis of the maternal and fetal circulation. Although the combination of multiple abnormal maternal serum analytes and abnormal Doppler findings is strongly associated with adverse outcomes, the predictive value remains too low to be used as a screening test in a low-risk population. Stratification of cases based on the severity of Doppler abnormalities may improve predictive models.

引用

页码：353 / +

页数：16

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