A vaccine for glioma

被引：7

作者：

Agnihotri, Sameer ^{[1
,2
]}

Yang, Kailin ^{[3
]}

Mitchell, Duane A. ^{[4
]}

Rich, Jeremy N. ^{[1
,5
]}

机构：

[1] Univ Pittsburgh, Hillman Canc Ctr, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Neurosurg, Pittsburgh, PA 15260 USA

[3] Cleveland Clin, Dept Radiat Oncol, Cleveland, OH 44106 USA

[4] Univ Florida, Dept Neurosurg, Gainesville, FL 32611 USA

[5] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

来源：

NATURE CANCER | 2021年 / 2卷 / 06期

关键词：

IDH1; INHIBITOR; MUTATIONS;

D O I：

10.1038/s43018-021-00228-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite substantial advances in understanding of the molecular features of gliomas, the therapeutic options for these aggressive tumors remain scarce. Rich, Mitchell and colleagues provide their views about a phase 1 clinical trial testing the safety and efficacy of vaccines against cancer expressing mutant metabolic enzyme IDH1 in patients with high-grade glioma.

引用

页码：584 / 586

页数：3

共 15 条

[1] Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate [J].

Andronesi, Ovidiu C. ;

Rapalino, Otto ;

Gerstner, Elizabeth ;

Chi, Andrew ;

Batchelor, Tracy T. ;

Cahil, Dan P. ;

Sorensen, A. Gregory ;

Rosen, Bruce R. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (09) :3659-3663

[2] Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas [J].

Brat, Daniel J. ;

Verhaak, Roel G. W. ;

Al-dape, Kenneth D. ;

Yung, W. K. Alfred ;

Salama, Sofie R. ;

Cooper, Lee A. D. ;

Rheinbay, Esther ;

Miller, C. Ryan ;

Vitucci, Mark ;

Morozova, Olena ;

Robertson, A. Gordon ;

Noushmehr, Houtan ;

Laird, Peter W. ;

Cherniack, Andrew D. ;

Akbani, Rehan ;

Huse, Jason T. ;

Ciriello, Giovanni ;

Poisson, Laila M. ;

Barnholtz-Sloan, Jill S. ;

Berger, Mitchel S. ;

Brennan, Cameron ;

Colen, Rivka R. ;

Colman, Howard ;

Flanders, Adam E. ;

Giannini, Caterina ;

Grifford, Mia ;

Iavarone, Antonio ;

Jain, Rajan ;

Joseph, Isaac ;

Kim, Jaegil ;

Kasaian, Katayoon ;

Mikkelsen, Tom ;

Murray, Bradley A. ;

O'Neill, Brian Patrick ;

Pachter, Lior ;

Parsons, Donald W. ;

Sougnez, Carrie ;

Sulman, Erik P. ;

Vandenberg, Scott R. ;

Van Meir, Erwin G. ;

von Deimling, Andreas ;

Zhang, Hailei ;

Crain, Daniel ;

Lau, Kevin ;

Mallery, David ;

Morris, Scott ;

Paulauskis, Joseph ;

Penny, Robert ;

Shelton, Troy ;

Sherman, Mark .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (26) :2481-2498

[3] Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate [J].

Bunse, Lukas ;

Pusch, Stefan ;

Bunse, Theresa ;

Sahm, Felix ;

Sanghvi, Khwab ;

Friedrich, Mirco ;

Alansary, Dalia ;

Sonner, Jana K. ;

Green, Edward ;

Deumelandt, Katrin ;

Kilian, Michael ;

Neftel, Cyril ;

Uhlig, Stefanie ;

Kessler, Tobias ;

von Landenberg, Anna ;

Berghoff, Anna S. ;

Marsh, Kelly ;

Steadman, Mya ;

Zhu, Dongwei ;

Nicolay, Brandon ;

Wiestler, Benedikt ;

Breckwoldt, Michael O. ;

Al-Ali, Ruslan ;

Karcher-Bausch, Simone ;

Bozza, Matthias ;

Oezen, Iris ;

Kramer, Magdalena ;

Meyer, Jochen ;

Habel, Antje ;

Eisel, Jessica ;

Poschet, Gernot ;

Weller, Michael ;

Preusser, Matthias ;

Nadji-Ohl, Minou ;

Thon, Niklas ;

Burger, Michael C. ;

Harter, Patrick N. ;

Ratliff, Miriam ;

Harbottle, Richard ;

Benner, Axel ;

Schrimpf, Daniel ;

Okun, Jurgen ;

Herold-Mende, Christel ;

Turcan, Sevin ;

Kaulfuss, Stefan ;

Hess-Stumpp, Holger ;

Bieback, Karen ;

Cahill, Daniel P. ;

Plate, Karl H. ;

Haenggi, Daniel .

NATURE MEDICINE, 2018, 24 (08) :1192-+

[4] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (vol 462, pg 739, 2010) [J].

Dang, Lenny ;

White, David W. ;

Gross, Stefan ;

Bennett, Bryson D. ;

Bittinger, Mark A. ;

Driggers, Edward M. ;

Fantin, Valeria R. ;

Jang, Hyun Gyung ;

Jin, Shengfang ;

Keenan, Marie C. ;

Marks, Kevin M. ;

Prins, Robert M. ;

Ward, Patrick S. ;

Yen, Katharine E. ;

Liau, Linda M. ;

Rabinowitz, Joshua D. ;

Cantley, Lewis C. ;

Thompson, Craig B. ;

Vander Heiden, Matthew G. ;

Su, Shinsan M. .

NATURE, 2010, 465 (7300) :966-966

[5] IDH mutation impairs histone demethylation and results in a block to cell differentiation [J].

Lu, Chao ;

Ward, Patrick S. ;

Kapoor, Gurpreet S. ;

Rohle, Dan ;

Turcan, Sevin ;

Abdel-Wahab, Omar ;

Edwards, Christopher R. ;

Khanin, Raya ;

Figueroa, Maria E. ;

Melnick, Ari ;

Wellen, Kathryn E. ;

O'Rourke, Donald M. ;

Berger, Shelley L. ;

Chan, Timothy A. ;

Levine, Ross L. ;

Mellinghoff, Ingo K. ;

Thompson, Craig B. .

NATURE, 2012, 483 (7390) :474-U130

[6] Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma [J].

Noushmehr, Houtan ;

Weisenberger, Daniel J. ;

Diefes, Kristin ;

Phillips, Heidi S. ;

Pujara, Kanan ;

Berman, Benjamin P. ;

Pan, Fei ;

Pelloski, Christopher E. ;

Sulman, Erik P. ;

Bhat, Krishna P. ;

Verhaak, Roel G. W. ;

Hoadley, Katherine A. ;

Hayes, D. Neil ;

Perou, Charles M. ;

Schmidt, Heather K. ;

Ding, Li ;

Wilson, Richard K. ;

Van Den Berg, David ;

Shen, Hui ;

Bengtsson, Henrik ;

Neuvial, Pierre ;

Cope, Leslie M. ;

Buckley, Jonathan ;

Herman, James G. ;

Baylin, Stephen B. ;

Laird, Peter W. ;

Aldape, Kenneth .

CANCER CELL, 2010, 17 (05) :510-522

[7] An integrated genomic analysis of human glioblastoma Multiforme [J].

Parsons, D. Williams ;

Jones, Sian ;

Zhang, Xiaosong ;

Lin, Jimmy Cheng-Ho ;

Leary, Rebecca J. ;

Angenendt, Philipp ;

Mankoo, Parminder ;

Carter, Hannah ;

Siu, I-Mei ;

Gallia, Gary L. ;

Olivi, Alessandro ;

McLendon, Roger ;

Rasheed, B. Ahmed ;

Keir, Stephen ;

Nikolskaya, Tatiana ;

Nikolsky, Yuri ;

Busam, Dana A. ;

Tekleab, Hanna ;

Diaz, Luis A., Jr. ;

Hartigan, James ;

Smith, Doug R. ;

Strausberg, Robert L. ;

Marie, Suely Kazue Nagahashi ;

Shinjo, Sueli Mieko Oba ;

Yan, Hai ;

Riggins, Gregory J. ;

Bigner, Darell D. ;

Karchin, Rachel ;

Papadopoulos, Nick ;

Parmigiani, Giovanni ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Kinzler, Kenneth W. .

SCIENCE, 2008, 321 (5897) :1807-1812

[8] A vaccine targeting mutant IDH1 in newly diagnosed glioma [J].

Platten, Michael ;

Bunse, Lukas ;

Wick, Antje ;

Bunse, Theresa ;

Le Cornet, Lucian ;

Harting, Inga ;

Sahm, Felix ;

Sanghvi, Khwab ;

Tan, Chin Leng ;

Poschke, Isabel ;

Green, Edward ;

Justesen, Sune ;

Behrens, Geoffrey A. ;

Breckwoldt, Michael O. ;

Freitag, Angelika ;

Rother, Lisa-Marie ;

Schmitt, Anita ;

Schnell, Oliver ;

Hense, Joerg ;

Misch, Martin ;

Krex, Dietmar ;

Stevanovic, Stefan ;

Tabatabai, Ghazaleh ;

Steinbach, Joachim P. ;

Bendszus, Martin ;

von Deimling, Andreas ;

Schmitt, Michael ;

Wick, Wolfgang .

NATURE, 2021, 592 (7854) :463-+

[9] D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma [J].

Pusch, Stefan ;

Schweizer, Leonille ;

Beck, Ann-Christin ;

Lehmler, Johanna-Marie ;

Weissert, Susanne ;

Balss, Joerg ;

Miller, Aubry K. ;

von Deimling, Andreas .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2014, 2

[10] An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells [J].

Rohle, Dan ;

Popovici-Muller, Janeta ;

Palaskas, Nicolaos ;

Turcan, Sevin ;

Grommes, Christian ;

Campos, Carl ;

Tsoi, Jennifer ;

Clark, Owen ;

Oldrini, Barbara ;

Komisopoulou, Evangelia ;

Kunii, Kaiko ;

Pedraza, Alicia ;

Schalm, Stefanie ;

Silverman, Lee ;

Miller, Alexandra ;

Wang, Fang ;

Yang, Hua ;

Chen, Yue ;

Kernytsky, Andrew ;

Rosenblum, Marc K. ;

Liu, Wei ;

Biller, Scott A. ;

Su, Shinsan M. ;

Brennan, Cameron W. ;

Chan, Timothy A. ;

Graeber, Thomas G. ;

Yen, Katharine E. ;

Mellinghoff, Ingo K. .

SCIENCE, 2013, 340 (6132) :626-630

← 1 2 →