Z-DNA: the long road to biological function

被引：410
作者：
Rich, A
Zhang, SG
机构：
[1] MIT, Dept Biol, Cambridge, MA 02139 USA
[2] MIT, Ctr Biomed Engn, Cambridge, MA 02139 USA
来源：
NATURE REVIEWS GENETICS | 2003年 / 4卷 / 07期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1038/nrg1115
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient localized conformational change. Few laboratories worked on the biology of Z-DNA. However, the discovery that certain classes of proteins bound to Z-DNA with high affinity and great specificity indicated a biological role. The most recent data show that some of these proteins participate in the pathology of poxviruses.
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收藏
页码：566 / 572
页数：7
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