Functionalized polyaniline based on protonic acid doping as a direct electron mediator to amplify sensor signals

被引：12
作者：
Zhao, Chulei [1 ]
Gao, Ke [1 ]
Ma, Chaoyun [1 ]
Wu, Mei [1 ]
Cao, Kaihang [1 ]
Yang, Yuxiao [1 ]
Hong, Chenglin [1 ]
Qiao, Xiuwen [1 ]
机构：
[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi, Xinjiang, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1209卷
基金：
中国国家自然科学基金;
关键词：
Protonic acid; PANI; AFP; HCS; AGGREGATION-INDUCED EMISSION; FLUORESCENT POLYMERIC NANOPARTICLES; SODIUM DODECYL-SULFATE; CARBON NANOTUBES; IMMUNOASSAY; FABRICATION; STRATEGY; NANOCOMPOSITES; AMPLIFICATION; NANOPROBES;
D O I：
10.1016/j.molstruc.2020.127924
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A "label-free" electrochemical immunosensor was developed to detect alpha-fetoprotein (AFP) sensitively. HCS@PANI (High carbonized nanospheres@Polyaniline) is used as an electrochemical sensing platform to improve conductivity and enhanche the amount of AFP antibody (anti-AFP) immobilized on the electrode surface. PANI, which is involved by protonic acid, exhibits excellent electrochemical activity and can be used as a direct electron mediator to further amplify electrochemical signals. Under optimal conditions, the electrochemical immunosensor has a linear range of 0.001-80 ng/mL and a minimum detection limit of 0.33 pg/mL. The immunosensor is expected to be used in clinical laboratories to detect AFP and other tumor markers in human plasma for precancerous screening or cancer surveillance. (C) 2020 Elsevier B.V. All rights reserved.
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页数：10
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