Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents

被引：43

作者：

Murty, M. S. R. ^{[1
]}

Ram, Kesur R. ^{[1
]}

Rao, Rayudu Venkateswara ^{[1
]}

Yadav, J. S. ^{[1
]}

Rao, Janapala Venkateswara ^{[2
]}

Cheriyan, Vino T. ^{[3
]}

Anto, Ruby John ^{[3
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Discovery Lab, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Toxicol Unit, Div Biol, Hyderabad 500607, Andhra Pradesh, India

[3] Rajiv Gandhi Ctr Biotechnol, Div Canc Res, Integrated Canc Res Program, Thycaud 695014, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2011年 / 20卷 / 05期

关键词：

Benzoxazole; Cyclic amine; Alkylation; Zinc; Anticancer; Cell lines; ANTIINFLAMMATORY PROPERTIES; BIOLOGICAL EVALUATION; ANTIMICROBIAL AGENTS; ACID-DERIVATIVES; 2(3H)-BENZOXAZOLONE; ANALOGS; UK-1; BENZOXAZOLONE; AGONISTS;

D O I：

10.1007/s00044-010-9353-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and cytotoxic activity studies of a new series of cyclic amine containing benzoxazole and benzoxazolone derivatives are described. The 2-cyclic amine-1,3-benzoxazoles 5a-k, 5-chloro-3-(3-chloropropyl)-1,3-benzoxazol-2(3H)-one 8 and 3-[3-(cyclic amino)propyl]-1,3-benzoxazol-2(3H)-ones 9a-f were synthesized. The newly synthesized compounds with the influence of the presence of cyclic amine moiety in the benzoxazole scaffold have been evaluated with respect to their cytotoxic effect toward four human cancer cell lines. The new compounds were evaluated to see whether substitution at the second and third position of the benzoxazole motif influence their cytotoxic effect toward cancer cells.

引用

页码：576 / 586

页数：11

共 33 条

[11] 4-(5-chloro-2(3H)-benzoxazolon-3-yl) butanoic acid derivatives: Synthesis, antinociceptive and anti-inflammatory properties [J].