High glucose up-regulates angiotensin II subtype 2 receptors via interferon regulatory factor-1 in proximal tubule epithelial cells

被引:17
作者
Ali, Quaisar [1 ]
Sabuhi, Rifat [1 ]
Hussain, Tahir [1 ]
机构
[1] Univ Houston, Coll Pharm, Heart & Kidney Inst, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA
关键词
Angiotensin receptors; Transcription factor; Hyperglycemia; Kidney; ACTIVATED PROTEIN-KINASE; OBESE ZUCKER RATS; TYPE-2; RECEPTOR; AT2; DIABETIC COMPLICATIONS; UNIFYING MECHANISM; GROWTH; TRANSCRIPTION; EXPRESSION; INJURY;
D O I
10.1007/s11010-010-0529-z
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Earlier studies have reported an increase in the proximal tubule AT(2) receptor (AT(2)R) expression in diabetes, with a beneficial role in kidney function and blood pressure regulation. Here, we demonstrate that the increase in AT(2)R protein expression is associated with an increased expression of transcription factor IRF-1 in hyperglycemic rat and in high glucose-treated HK2 cells. Knock-down of IRF-1 by siRNA in HK2 cells prevented high glucose-induced AT(2)R up-regulation. The data suggest that IRF-1 is a transcriptional regulator of AT(2)R expression in hyperglycemia, and warrant further studies to understand the physiological role of IRF-1 along with AT(2)R in diabetic kidney.
引用
收藏
页码:65 / 71
页数:7
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