Dynamic Characteristic Analysis of HIV Mother to Child Transmission in China

被引：7

作者：

Wang, Jun-Jie ^{[1
]}

Reilly, Kathleen Heather ^{[1
,2
]}

Han, Hua ^{[3
]}

Peng, Zhi-Hang ^{[4
]}

Wang, Ning ^{[1
]}

机构：

[1] China Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing 100050, Peoples R China

[2] Tulane Univ, Sch Publ Hlth & Trop Med, Hlth Sci Ctr, New Orleans, LA USA

[3] Chinese Acad Sci, Inst Automat, Natl ASIC Design Engn Ctr, Beijing 100190, Peoples R China

[4] Nanjing Med Univ, Dept Epidemiol & Biostat, Nanjing 210029, Peoples R China

来源：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2010年 / 23卷 / 05期

关键词：

mother to child transmission; dynamic model; HIV; China; IMMUNODEFICIENCY-VIRUS TYPE-1; ACTIVE ANTIRETROVIRAL THERAPY; PREGNANT-WOMEN; INFECTION; PREVENTION; SURVIVAL; HIV/AIDS; INFANTS; PREVALENCE; MODEL;

D O I：

10.1016/S0895-3988(10)60082-7

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective to explore dynamic characteristics of the HIV mother to child transmission (MTCT) epidemic in China. Methods A deterministic dynamic transmission model was used to determine the effect of key parameters on the likely long-term trends of the HIV MTCT epidemic in China. Matlab 7.0 was used to develop the model. Results The number of the susceptibles (S), the transmission rate (beta), and the screening proportion (alpha) of HIV positive pregnant women have the greatest impact on the HIV MTCT epidemic in China. The growth of the MTCT epidemic in China could not be controlled only by decreasing the MTCT transmission rate. The prevalence of HIV positive women should be reduced and more pregnant women should be tested for HIV. Conclusion Prevention of MTCT (PMTCT) should focus not only on the reduction of HIV transmission rates and incidences of HIV among women but also on the increase of HIV testing for pregnant women. The most cost-effective PMTCT means for China should be investigated in future studies.

引用

页码：402 / 408

页数：7

共 43 条

[1]

[Anonymous], 2009, Progress Report'

[2]

[Anonymous], 2008, CHIN J AIDS STD, DOI DOI 10.3969/J.ISSN.1672-5662.2008.05.001

[3] Universal Antiretroviral Therapy for Pregnant and Breast-Feeding HIV-1-Infected Women: Towards the Elimination of Mother-to-Child Transmission of HIV-1 in Resource-Limited Settings [J].

Becquet, Renaud ;

Ekouevi, Didier K. ;

Arrive, Elise ;

Stringer, Jeffrey S. A. ;

Meda, Nicolas ;

Chaix, Marie-Laure ;

Treluyer, Jean-Marc ;

Leroy, Valeriane ;

Rouzioux, Christine ;

Blanche, Stephane ;

Dabis, Francois .

CLINICAL INFECTIOUS DISEASES, 2009, 49 (12) :1936-1945

[4] Mathematical models for HIV transmission dynamics - Tools for social and behavioral science research [J].

Cassels, Susan ;

Clark, Samuel J. ;

Morris, Martina .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2008, 47 :S34-S39

[5] Mother to child transmission of HIV in China - The numbers are small but rising, and two provinces have worrying HIV prevalence rates in pregnant women [J].

Chen, KT ;

Qian, HZ .

BRITISH MEDICAL JOURNAL, 2005, 330 (7503) :1282-1283

[6] Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study [J].

Coovadia, Hoosen M. ;

Rollins, Nigel C. ;

Bland, Ruth M. ;

Little, Kirsty ;

Coutsoudis, Anna ;

Bennish, Michael L. ;

Newell, Marie-Louise .

LANCET, 2007, 369 (9567) :1107-1116

[7]

[邓莉平 Deng Liping], 2005, [中华传染病杂志, Chinese Journal of Infections Diseases], V23, P183

[8] Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model [J].

Granich, Reuben M. ;

Gilks, Charles F. ;

Dye, Christopher ;

De Cock, Kevin M. ;

Williams, Brian G. .

LANCET, 2009, 373 (9657) :48-57

[9]

GUI X, 2003, CHIN J PEDIAT, V41, P586

[10] Mathematical study of a staged-progression HIV model with imperfect vaccine [J].

Gumel, A. B. ;

McCluskey, Connell C. ;

van den Driessche, P. .

BULLETIN OF MATHEMATICAL BIOLOGY, 2006, 68 (08) :2105-2128

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