Neonatal Status Epilepticus

被引：22

作者：

Lawrence, Russell ^{[1
,2
]}

Inder, Terrie ^{[1
,3
]}

机构：

[1] Washington Univ, Dept Pediat, St Louis, MO 63130 USA

[2] Washington Univ, Dept Neurol, St Louis, MO USA

[3] Cook Childrens Hosp, Ft Worth, TX USA

来源：

SEMINARS IN PEDIATRIC NEUROLOGY | 2010年 / 17卷 / 03期

关键词：

ANTIEPILEPTIC DRUGS; RECEPTOR CHANNELS; DEVELOPING BRAIN; SEIZURES; TOPIRAMATE; EXPRESSION; SUSCEPTIBILITY; PERMEABILITY; BUMETANIDE; EPILEPSY;

D O I：

10.1016/j.spen.2010.06.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seizures are more prevalent during the neonatal period than at any other time in the human lifespan. During early development, neonates are developmentally predisposed to excitatory neuronal activity increasing their susceptibility to seizures. Status epilepticus is poorly defined in this subpopulation with a lack of a consensus definition. In this review, we discuss the common etiologies of recurrent seizures in the newborn in addition to current trends on monitoring and treatment. Finally, we discuss the current evidence in both animal and human studies that indicate that neonatal seizures may be harmful to the immature brain with adverse long-term neurodevelopment outcomes. Semin Pediatr Neurol 17:163-168 (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：163 / 168

页数：6

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