N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes

被引：51
|
作者：
Wang, Y. [1 ]
McAlpine, S. R. [1 ]
机构：
[1] Univ New S Wales, Dept Chem, Sydney, NSW 2052, Australia
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 08期
关键词：
HEAT-SHOCK-PROTEIN; INHIBITOR; SANSALVAMIDE; EXPRESSION; CELLS; HSF1; RESISTANCE; DISTINCT; TARGETS; BINDING;
D O I：
10.1039/c4cc07284g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Classic oncogenic heat shock protein 90 (Hsp90) inhibitors target the N-terminus of the protein, triggering a survival mechanism in cancer cells referred to as the heat shock response (HSR). Inhibiting Hsp90 by modulating the C-terminus does not trigger a HSR, making it a highly attractive chemotherapeutic approach.
引用
收藏
页码：1410 / 1413
页数：4
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