Metal-organic frameworks based on β-cyclodextrin: design and selective entrapment of non-steroidal anti-inflammatory drugs

被引：38

作者：

Volkova, Tatyana ^{[1
]}

Surov, Artem ^{[1
]}

Terekhova, Irina ^{[1
]}

机构：

[1] Russian Acad Sci, GA Krestov Inst Solut Chem, 1 Akad Skaya Str, Ivanovo 153045, Russia

来源：

JOURNAL OF MATERIALS SCIENCE | 2020年 / 55卷 / 27期

基金：

俄罗斯基础研究基金会;

关键词：

CD-MOF; CRYSTAL TRANSFORMATION; IBUPROFEN; SOLUBILITY; ENCAPSULATION; STABILITY; CARRIERS; PHASE;

D O I：

10.1007/s10853-020-04937-4

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Metal-organic frameworks based on beta-cyclodextrin and potassium cations (K-beta CD-MOF) were synthesized and characterized. Influence of nature and amount of anti-solvent, as well as molar ratio of the components and temperature on the K-beta CD-MOF synthesis was revealed. The loading of non-steroidal anti-inflammatory drugs (NSAIDs) in K-beta CD-MOF was performed by co-crystallization and impregnation methods. It was shown that chemical nature of NSAIDs strongly influences the drug loading. The maximum payload (up to 7 wt%) was reached for ibuprofen as less bulky and more lipophilic compound. The obtained composites were characterized by different experimental techniques. Ibuprofen entrapped in K-beta CD-MOF displayed improved aqueous solubility. Solubility rise is caused by formation of the inclusion complexes and clusters stabilized by beta-CD.

引用

页码：13193 / 13205

页数：13

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