Emergence and evolution of virulence in human pathogenic fungi

被引：37

作者：

Siscar-Lewin, Sofia ^{[1
]}

Hube, Bernhard ^{[1
,2
]}

Brunke, Sascha ^{[1
]}

机构：

[1] Hans Knoell Inst, Dept Microbial Pathogenic Mech, Jena, Germany

[2] Friedrich Schiller Univ, Inst Microbiol, Jena, Germany

来源：

TRENDS IN MICROBIOLOGY | 2022年 / 30卷 / 07期

基金：

欧盟地平线“2020”;

关键词：

BLOOD-STREAM INFECTIONS; SMALL COLONY VARIANTS; CANDIDA-ALBICANS; ASPERGILLUS-FUMIGATUS; GENES; GUT; NEOFORMANS; COMMENSAL; ANTIVIRULENCE; EPIDEMIOLOGY;

D O I：

10.1016/j.tim.2021.12.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One billion people worldwide are affected by fungal pathogens, of which 1.6 million succumb to fungal infections per year. This review discusses the emergence and evolution of fungal pathogenesis in humans in the form of opportunistic commensal and environmental fungi. We explore the attributes that contribute to their success as pathogens and the scenarios which may have caused the evolutionary selection of virulence factors. This includes antivirulence and avirulence genes, notions that are new for fungal pathogens of humans but which are based on well established concepts in bacterial pathogens and phytopathogenic fungi. These ideas will ultimately help us to better understand the pathogenicity of fungi that infect humans: from the emergence to the finer adjustment of virulence to promote pathogen persistence.

引用

页码：693 / 704

页数：12

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