Rapid development of a DNA vaccine for Zika virus

被引：333

作者：

Dowd, Kimberly A. ^{[1
]}

Ko, Sung-Youl ^{[2
]}

Morabito, Kaitlyn M. ^{[2
]}

Yang, Eun Sung ^{[2
]}

Pelc, Rebecca S. ^{[1
]}

DeMaso, Christina R. ^{[1
]}

Castilho, Leda R. ^{[2
,3
]}

Abbink, Peter ^{[4
]}

Boyd, Michael ^{[4
]}

Nityanandam, Ramya ^{[4
]}

Gordon, David N. ^{[1
]}

Gallagher, John Robert ^{[5
]}

Chen, Xuejun ^{[2
]}

Todd, John-Paul ^{[2
]}

Tsybovsky, Yaroslav ^{[6
]}

Harris, Audray ^{[5
]}

Huang, Yan-Jang S. ^{[7
]}

Higgs, Stephen ^{[7
]}

Vanlandingham, Dana L. ^{[7
]}

Andersen, Hanne ^{[8
]}

Lewis, Mark G. ^{[8
]}

De La Barrera, Rafael ^{[9
]}

Eckels, Kenneth H. ^{[9
]}

Jarman, Richard G. ^{[10
]}

Nason, Martha C. ^{[11
]}

Barouch, Dan H. ^{[4
]}

Roederer, Mario ^{[2
]}

Kong, Wing-Pui ^{[2
]}

Mascola, John R. ^{[2
]}

Pierson, Theodore C. ^{[1
]}

Graham, Barney S. ^{[2
]}

机构：

[1] NIAID, Viral Pathogenesis Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] Univ Fed Rio de Janeiro, COPPE, Chem Engn Program, Inst Alberto Luiz Coimbra Posgrad & Pesquisa Engn, Rio De Janeiro, Brazil

[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[5] NIAID, Struct Informat Unit, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[6] Frederick Natl Lab Canc Res, Electron Microscopy Lab, Canc Res Technol Program, Frederick, MD 21702 USA

[7] Kansas State Univ, Coll Vet Med, Dept Diagnost Med Pathobiol, Manhattan, KS 66506 USA

[8] Bioqual, Rockville, MD 20852 USA

[9] Walter Reed Army Inst Res, Translat Med Branch, Silver Spring, MD 20910 USA

[10] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA

[11] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20852 USA

来源：

SCIENCE | 2016年 / 354卷 / 6309期

关键词：

JAPANESE ENCEPHALITIS-VIRUS; TICK-BORNE ENCEPHALITIS; DENGUE VIRUS; CANDIDATE VACCINE; HEALTHY-ADULTS; ANTIBODY; NEUTRALIZATION; PREMEMBRANE; PROTECTION; CHALLENGE;

D O I：

10.1126/science.aai9137

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal risk from endemic disease and travel-related exposures, a vaccine to prevent viremia in women of childbearing age and their partners is imperative. We found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZIKV challenge correlated with serum neutralizing activity. These data not only indicate that DNA vaccination could be a successful approach to protect against ZIKV infection, but also suggest a protective threshold of vaccine induced neutralizing activity that prevents viremia after acute infection.

引用

页码：237 / 240

页数：5

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